Literature DB >> 12560036

Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica.

Lie-Chwen Lin1, Ling-Ling Yang, Cheng-Jen Chou.   

Abstract

Two plumbagic acid glucosides, 3'-O-beta-glucopyranosyl plumbagic acid and 3'-O-beta-glucopyranosyl plumbagic acid methylester along with five naphthoquinones (plumbagin, chitranone, maritinone, elliptinone and isoshinanolone), and five coumarins (seselin, 5-methoxyseselin, suberosin, xanthyletin and xanthoxyletin) were isolated from the roots of Plumbago zeylanica. All coumarins were not previously found in this plant. Cytotoxicity of these compounds to various tumor cells lines was evaluated, and plumbagin significantly suppressed growth of Raji, Calu-1, HeLa, and Wish tumor cell lines.

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Year:  2003        PMID： 12560036     DOI： 10.1016/s0031-9422(02)00519-8

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


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