BACKGROUND: Solanum melongena L. (Solanaceae) has antioxidant, analgesic, hypolipidemic and antiallergic activity. METHODS: The anti-inflammatory effects of the water extract of the S. melongena (SMWE) were investigated in PAR2-mediated mouse paw edema. Paw edema was induced by injection of trypsin or trans-cinnamoyl-LIGRLO-NH(2) (tc-NH(2)) into the hindpaw of mice. The SMWE (1, 5, 10, and 100 mg/kg) was orally administered 1 h before induction of inflammation. RESULTS: At doses of 5, 10, and 100 mg/kg, the SMWE showed significant inhibition of both paw edema and vascular permeability. The SMWE (10 mg/kg) significantly also inhibited PAR2 agonist-induced myeloperoxidase (MPO) activity and tumor necrosis factor (TNF)-alpha expression in paw tissue. CONCLUSION: These results demonstrate that the SMWE inhibits PAR2 agonist-induced mouse paw edema. Copyright 2002 Elsevier Science B.V.
BACKGROUND:Solanum melongena L. (Solanaceae) has antioxidant, analgesic, hypolipidemic and antiallergic activity. METHODS: The anti-inflammatory effects of the water extract of the S. melongena (SMWE) were investigated in PAR2-mediated mouse paw edema. Paw edema was induced by injection of trypsin or trans-cinnamoyl-LIGRLO-NH(2) (tc-NH(2)) into the hindpaw of mice. The SMWE (1, 5, 10, and 100 mg/kg) was orally administered 1 h before induction of inflammation. RESULTS: At doses of 5, 10, and 100 mg/kg, the SMWE showed significant inhibition of both paw edema and vascular permeability. The SMWE (10 mg/kg) significantly also inhibited PAR2 agonist-induced myeloperoxidase (MPO) activity and tumor necrosis factor (TNF)-alpha expression in paw tissue. CONCLUSION: These results demonstrate that the SMWE inhibits PAR2 agonist-induced mouse paw edema. Copyright 2002 Elsevier Science B.V.
Authors: Loredana Salerno; Maria N Modica; Valeria Pittalà; Giuseppe Romeo; Maria A Siracusa; Claudia Di Giacomo; Valeria Sorrenti; Rosaria Acquaviva Journal: ScientificWorldJournal Date: 2014-02-09
Authors: Francesco Di Gioia; Nikolaos Tzortzakis; Youssef Rouphael; Marios C Kyriacou; Shirley L Sampaio; Isabel C F R Ferreira; Spyridon A Petropoulos Journal: Antioxidants (Basel) Date: 2020-01-23