Literature DB >> 12558830

Clues to the genetic influences of drug responsiveness in epilepsy.

V Ramachandran1, Simon D Shorvon.   

Abstract

Despite the introduction of newer antiepileptic drugs (AEDs), nonresponsiveness to AEDs remains a common problem in epilepsy clinics. There may be important genetic determinants for responsiveness, and this discussion focused on some potential areas: drug transporters; drug-metabolizing enzymes, and ion channels. We review the literature and speculate the contribution of each of these factors in management of patients with epilepsy in the future.

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Year:  2003        PMID： 12558830     DOI： 10.1046/j.1528-1157.44.s.1.13.x

Source DB:  PubMed          Journal:  Epilepsia        ISSN： 0013-9580            Impact factor:   5.864


  4 in total

1.  Pharmacogenetics of epilepsy: one step forward?

Authors:  Graeme J Sills
Journal:  Epilepsy Curr       Date:  2005 Nov-Dec       Impact factor: 7.500

2.  Pharmacogenomic association study on the role of drug metabolizing, drug transporters and drug target gene polymorphisms in drug-resistant epilepsy in a north Indian population.

Authors:  Ritu Kumari; Ram Lakhan; R K Garg; J Kalita; U K Misra; Balraj Mittal
Journal:  Indian J Hum Genet       Date:  2011-05

3.  The likelihood approach for potential role of "GABRG2 (C588T, C315T) gene polymorphisms" on the poor response to carbamazepine therapy in Pakhtun population of Pakistan.

Authors:  Shakir Ullah; Niaz Ali; Sajjad Ahmad; Syed Wadood Ali Sha; Saad Ali; Feras Almarshad
Journal:  Medicine (Baltimore)       Date:  2022-10-07       Impact factor: 1.817

Review 4.  Research Progress on the Role of ABC Transporters in the Drug Resistance Mechanism of Intractable Epilepsy.

Authors:  Jie Xiong; Ding-An Mao; Li-Qun Liu
Journal:  Biomed Res Int       Date:  2015-09-27       Impact factor: 3.411
  4 in total

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