OBJECTIVE: We performed spike triggered functional MRI (fMRI) in a 12 year old girl with Benign Epilepsy with Centro-temporal Spikes (BECTS) and left-sided spikes. Our aim was to demonstrate the cerebral origin of her interictal spikes. METHODS: EEG was recorded within the 3 Tesla MRI. Whole brain fMRI images were acquired, beginning 2-3 seconds after spikes. Baseline fMRI images were acquired when there were no spikes for 20 seconds. Image sets were compared with the Student's t-test. RESULTS: Ten spike and 20 baseline brain volumes were analysed. Focal activiation was seen in the inferior left sensorimotor cortex near the face area. The anterior cingulate was more active during baseline than spikes. CONCLUSIONS: Left sided epileptiform activity in this patient with BECTS is associated with fMRI activation in the left face region of the somatosensory cortex, which would be consistent with the facial sensorimotor involvement in BECT seizures. The presence of BOLD signal change in other regions raises the possibility that the scalp recorded field of this patient with BECTs may reflect electrical change in more than one brain region.
OBJECTIVE: We performed spike triggered functional MRI (fMRI) in a 12 year old girl with Benign Epilepsy with Centro-temporal Spikes (BECTS) and left-sided spikes. Our aim was to demonstrate the cerebral origin of her interictal spikes. METHODS: EEG was recorded within the 3 Tesla MRI. Whole brain fMRI images were acquired, beginning 2-3 seconds after spikes. Baseline fMRI images were acquired when there were no spikes for 20 seconds. Image sets were compared with the Student's t-test. RESULTS: Ten spike and 20 baseline brain volumes were analysed. Focal activiation was seen in the inferior left sensorimotor cortex near the face area. The anterior cingulate was more active during baseline than spikes. CONCLUSIONS: Left sided epileptiform activity in this patient with BECTS is associated with fMRI activation in the left face region of the somatosensory cortex, which would be consistent with the facial sensorimotor involvement in BECT seizures. The presence of BOLD signal change in other regions raises the possibility that the scalp recorded field of this patient with BECTs may reflect electrical change in more than one brain region.
Authors: Loes Koelewijn; Khalid Hamandi; Lisa M Brindley; Matthew J Brookes; Bethany C Routley; Suresh D Muthukumaraswamy; Natalie Williams; Marie A Thomas; Amanda Kirby; Johann Te Water Naudé; Frances Gibbon; Krish D Singh Journal: Hum Brain Mapp Date: 2015-07-14 Impact factor: 5.038
Authors: Julia Jacobs; Colin Hawco; Eliane Kobayashi; Rainer Boor; Pierre LeVan; Ulrich Stephani; Michael Siniatchkin; Jean Gotman Journal: Neuroimage Date: 2007-12-15 Impact factor: 6.556
Authors: Katarzyna Blinowska; Gernot Müller-Putz; Vera Kaiser; Laura Astolfi; Katrien Vanderperren; Sabine Van Huffel; Louis Lemieux Journal: Comput Intell Neurosci Date: 2009-06-15