| Literature DB >> 1255761 |
W T Speck, A B Stein, H S Rosenkranz.
Abstract
Mutagenic activity was found in the urine of 10 patients given therapeutic dosages of metronidazole orally or per vagina. Paper chromatographic separation revealed that mutagenicity in the urine was associated with unmodified metronidazole and at least four of its known urinary metabolites. Activity was also recovered in a region of the chromatogram heretofore not assigned to a metronidazole metabolite.Entities:
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Year: 1976 PMID： 1255761 DOI： 10.1093/jnci/56.2.283
Source DB: PubMed Journal: J Natl Cancer Inst ISSN： 0027-8874 Impact factor: 13.506