AIMS: We analysed the MAOAuVNTR functional polymorphism in the promoter region of the X-chromosomal monoamine oxidase A (MAOA) gene. Genotypes with three-repeat alleles were reported to be associated with antisocial as well as impulsive traits. METHODS: The repeat number (3-5) of the MAOA polymorphism was determined in 169 male alcoholic subjects and 72 controls of German descent. Behavioural and personality traits were evaluated using the Brown-Goodwin Assessment for History of Lifetime Aggression, the Buss Durkee Hostility Inventory, as well as the Barrat Impulsiveness Score. A median split in Brown-Goodwin, Buss Durkee Irritability, Buss Durkee Assault and Barrat Impulsiveness Score was conducted. RESULTS: High scores were found, i.e. 47.9% in Brown-Goodwin, 65.7% in Buss Durkee Irritability, 63.3% in Buss Durkee Assault and 59.8% in Barrat Impulsiveness Scale, indicating high impulsiveness, irritability and antisocial behaviour. Based on the results of these questionnaires, we detected no significant differences between the frequency of the three-repeat allele and high or low scores in alcoholics and controls. CONCLUSIONS: Taken together, these findings suggest that the three-repeat allele of the MAOAuVNTR 30-bp polymorphism is not associated with impulsive and aggressive personality traits.
AIMS: We analysed the MAOAuVNTR functional polymorphism in the promoter region of the X-chromosomal monoamine oxidase A (MAOA) gene. Genotypes with three-repeat alleles were reported to be associated with antisocial as well as impulsive traits. METHODS: The repeat number (3-5) of the MAOA polymorphism was determined in 169 male alcoholic subjects and 72 controls of German descent. Behavioural and personality traits were evaluated using the Brown-Goodwin Assessment for History of Lifetime Aggression, the Buss Durkee Hostility Inventory, as well as the Barrat Impulsiveness Score. A median split in Brown-Goodwin, Buss Durkee Irritability, Buss Durkee Assault and Barrat Impulsiveness Score was conducted. RESULTS: High scores were found, i.e. 47.9% in Brown-Goodwin, 65.7% in Buss Durkee Irritability, 63.3% in Buss Durkee Assault and 59.8% in Barrat Impulsiveness Scale, indicating high impulsiveness, irritability and antisocial behaviour. Based on the results of these questionnaires, we detected no significant differences between the frequency of the three-repeat allele and high or low scores in alcoholics and controls. CONCLUSIONS: Taken together, these findings suggest that the three-repeat allele of the MAOAuVNTR 30-bp polymorphism is not associated with impulsive and aggressive personality traits.
Authors: Lars Oreland; Gianvito Lagravinese; Simone Toffoletto; Kent W Nilsson; Jaanus Harro; C Robert Cloninger; Erika Comasco Journal: J Neural Transm (Vienna) Date: 2017-01-04 Impact factor: 3.575
Authors: Agnes L Nishimura; Camila Guindalini; João R M Oliveira; Ricardo Nitrini; Valéria S Bahia; Paulo R de Brito-Marques; Paulo A Otto; Mayana Zatz Journal: J Mol Neurosci Date: 2005 Impact factor: 3.444
Authors: Robert A Philibert; Tracy D Gunter; Steven R H Beach; Gene H Brody; Anup Madan Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2008-07-05 Impact factor: 3.568
Authors: Agnieszka Samochowiec; Magdalena Chęć; Edyta Kopaczewska; Jerzy Samochowiec; Otto Lesch; Elżbieta Grochans; Andrzej Jasiewicz; Przemyslaw Bienkowski; Kołodziej Łukasz; Anna Grzywacz Journal: Int J Environ Res Public Health Date: 2015-03-19 Impact factor: 3.390