OBJECTIVES: Our aim was to assess the oxidative stress in tumor tissues of oral cancer patients by measuring the levels of lipids, thiobarbituric acid reactive substances (TBARS) and antioxidants. DESIGN AND METHODS: This study has been conducted on oral tumor tissues of 48 adult male oral cancer patients with various clinical stages (stage II to stage IV; 16 of each) and normal tissues of an equal number of age and sex matched disease free healthy subjects. The levels of lipids, lipid peroxidation and antioxidants in buccal mucosa of healthy subjects and oral cancer patients were assayed using colorimetric methods, except for vitamin E (fluorometriy). RESULTS: Total cholesterol and esterified cholesterol were markedly increased whereas phospholipids and free fatty acids were significantly decreased in tumor tissues as compared to normal tissues. The decrease in TBARS levels and functional compromise of antioxidant defense mechanisms were observed in the tumor tissues as compared to normal subjects. CONCLUSIONS: The low availability of peroxidizable substrates and the enhanced antioxidant capacity in tumor tissues make them less susceptible to oxidative stress, conferring a selective growth advantage on tumor cells.
OBJECTIVES: Our aim was to assess the oxidative stress in tumor tissues of oral cancerpatients by measuring the levels of lipids, thiobarbituric acid reactive substances (TBARS) and antioxidants. DESIGN AND METHODS: This study has been conducted on oral tumor tissues of 48 adult male oral cancerpatients with various clinical stages (stage II to stage IV; 16 of each) and normal tissues of an equal number of age and sex matched disease free healthy subjects. The levels of lipids, lipid peroxidation and antioxidants in buccal mucosa of healthy subjects and oral cancerpatients were assayed using colorimetric methods, except for vitamin E (fluorometriy). RESULTS: Total cholesterol and esterified cholesterol were markedly increased whereas phospholipids and free fatty acids were significantly decreased in tumor tissues as compared to normal tissues. The decrease in TBARS levels and functional compromise of antioxidant defense mechanisms were observed in the tumor tissues as compared to normal subjects. CONCLUSIONS: The low availability of peroxidizable substrates and the enhanced antioxidant capacity in tumor tissues make them less susceptible to oxidative stress, conferring a selective growth advantage on tumor cells.
Authors: Vera F Monteiro-Cardoso; Amélia M Silva; Maria M Oliveira; Francisco Peixoto; Romeu A Videira Journal: J Bioenerg Biomembr Date: 2014-02 Impact factor: 2.945
Authors: Giju Thomas; Johan van Voskuilen; Hoa Truong; Ji-Ying Song; Hans C Gerritsen; H J C M Sterenborg Journal: Biomed Opt Express Date: 2014-11-13 Impact factor: 3.732
Authors: Fatih Comert; Alexander Greenwood; Joseph Maramba; Roderico Acevedo; Laura Lucas; Thulasi Kulasinghe; Leah S Cairns; Yi Wen; Riqiang Fu; Janet Hammer; Jack Blazyk; Sergei Sukharev; Myriam L Cotten; Mihaela Mihailescu Journal: J Biol Chem Date: 2019-10-16 Impact factor: 5.157