BACKGROUND: The epidemiology of Chlamydia trachomatis infection in men is not well defined, especially among those who are asymptomatic or show no signs of infection. Established C. trachomatis screening programs for women have demonstrated the benefit of routine screening in reducing prevalence over time, but the yield and benefit of screening asymptomatic men are unclear. METHODS: Cross-sectional study of C. trachomatis prevalence and associated risk factors among men tested at sexually transmitted disease (STD) clinics in Alaska, Idaho, Oregon, and Washington. We analyzed data from 43,094 men universally tested from 1997 to 1999 at 103 STD clinics, and assessed age-specific prevalence of infection, controlling for signs of infection (urethritis diagnosed by clinician) and report of sexual contact to a person with an STD (defined as "contact"). RESULTS: Overall prevalence of C. trachomatis was 10.3%. Age-specific prevalence was highest among men aged 18 to 19 years and lowest among those aged >29 years, regardless of signs of infection upon examination or contact to a person with an STD. If these factors and age <25 years had been used to direct C. trachomatis testing at STD clinics, 59% of men would have been tested and 91% of positives would have been detected. CONCLUSIONS: Using either the presence of clinical signs or report of a sex partner with an STD in combination with selective screening of all men aged <25 years detects the majority of infections and, in our population, would have considerably reduced the number of negative tests performed.
BACKGROUND: The epidemiology of Chlamydia trachomatis infection in men is not well defined, especially among those who are asymptomatic or show no signs of infection. Established C. trachomatis screening programs for women have demonstrated the benefit of routine screening in reducing prevalence over time, but the yield and benefit of screening asymptomatic men are unclear. METHODS: Cross-sectional study of C. trachomatis prevalence and associated risk factors among men tested at sexually transmitted disease (STD) clinics in Alaska, Idaho, Oregon, and Washington. We analyzed data from 43,094 men universally tested from 1997 to 1999 at 103 STD clinics, and assessed age-specific prevalence of infection, controlling for signs of infection (urethritis diagnosed by clinician) and report of sexual contact to a person with an STD (defined as "contact"). RESULTS: Overall prevalence of C. trachomatis was 10.3%. Age-specific prevalence was highest among men aged 18 to 19 years and lowest among those aged >29 years, regardless of signs of infection upon examination or contact to a person with an STD. If these factors and age <25 years had been used to direct C. trachomatis testing at STD clinics, 59% of men would have been tested and 91% of positives would have been detected. CONCLUSIONS: Using either the presence of clinical signs or report of a sex partner with an STD in combination with selective screening of all men aged <25 years detects the majority of infections and, in our population, would have considerably reduced the number of negative tests performed.
Authors: S Levidiotou; G Vrioni; H Papadogeorgaki; K Avdeliodi; H Kada; G Kaparos; E Kouskouni; E Fragouli; N J Legakis Journal: Eur J Clin Microbiol Infect Dis Date: 2005-03 Impact factor: 3.267
Authors: Sumin Cai; Feng He; Hardeep S Samra; Luis M de la Maza; Maria E Bottazzi; Sangeeta B Joshi; C Russell Middaugh Journal: Mol Pharm Date: 2009 Sep-Oct Impact factor: 4.939
Authors: Guilherme Almeida Rosa da Silva; Heloisa Loureiro de Sá Neves Motta; Erik Friedrich Alex de Souza; Pedro Afonso Nogueira Moises Cardoso; José Henrique Pilotto; Walter Araujo Eyer-Silva; Luiz Cláudio Pereira Ribeiro; Mônica Soares Dos Santos; Marcelo Costa Velho Mendes de Azevedo; Jorge Francisco da Cunha Pinto; Rogerio Neves Motta; Fernando Raphael de Almeida Ferry Journal: Rev Inst Med Trop Sao Paulo Date: 2018-03-08 Impact factor: 1.846