Effects of low-toxicity particulate matter on human nasal function.

Chronic nasal and paranasal sinus problems affect approximately 15% of the population in industrialized countries. Recent studies suggest that particulate matter might contribute to this condition. The effects of acute exposure to low-toxicity particulate matter on human nasal airflow, mucociliary transport, and nasal discomfort should be assessed. Thirty-two healthy volunteers were exposed to 0 (control), 500, 1000, and 5000 micrograms/m3 calcium carbonate dust for 3 hours and nasal saccharin transport time (STT), rhinomanometry, and visual analog scales (VAS) on nasal discomfort were obtained. A dose dependent decrease of STT (P = 0.02) and nasal patency (P = 0.04), and increased sensation of nasal obstruction (P = 0.002) and dryness (P = 0.03) was observed. The results indicate that acute exposure to low-toxicity particulate matter in concentrations frequently encountered in western agglomeration areas may affect nasal functions and cause nasal symptoms.