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Literature DB >> 12552017

Targeted retroviral infection of tumor cells by receptor cooperation.

Francisco Martin¹, Simon Chowdhury, Stuart J Neil, Kerry A Chester, Francois-Loic Cosset, Mary K Collins.

Abstract

Retroviruses expressing two different receptor-binding domains linked by proline-rich spacers infect only cells expressing both retroviral receptors (Valsesia-Wittman et al., EMBO J. 6:1214-1223, 1997). Here we apply this receptor cooperation strategy to target human tumor cells by linking single-chain antibodies recognizing tumor antigens via proline-rich spacers to the 4070A murine leukemia virus surface protein.

Entities: Chemical Disease Species

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Year: 2003 PMID： 12552017 PMCID： PMC141083 DOI： 10.1128/jvi.77.4.2753-2756.2003

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

26 in total

1. Receptor co-operation in retrovirus entry: recruitment of an auxiliary entry mechanism after retargeted binding.

Authors: S Valsesia-Wittmann; F J Morling; T Hatziioannou; S J Russell; F L Cosset
Journal: EMBO J Date: 1997-03-17 Impact factor: 11.598

2. A proline-rich motif downstream of the receptor binding domain modulates conformation and fusogenicity of murine retroviral envelopes.

Authors: D Lavillette; M Maurice; C Roche; S J Russell; M Sitbon; F L Cosset
Journal: J Virol Date: 1998-12 Impact factor: 5.103

3. High-titer packaging cells producing recombinant retroviruses resistant to human serum.

Authors: F L Cosset; Y Takeuchi; J L Battini; R A Weiss; M K Collins
Journal: J Virol Date: 1995-12 Impact factor: 5.103

4. Generation and selection of monoclonal antibodies, single-chain Fv and antibody fusion phage specific for human melanoma-associated antigens.

Authors: J M Kupsch; N Tidman; J A Bishop; I McKay; I Leigh; J S Crowe
Journal: Melanoma Res Date: 1995-12 Impact factor: 3.599

5. Selective transduction of protease-rich tumors by matrix-metalloproteinase-targeted retroviral vectors.

Authors: K W Peng; R Vile; F L Cosset; S Russell
Journal: Gene Ther Date: 1999-09 Impact factor: 5.250

6. Gene therapy with autologous, interleukin 2-secreting tumor cells in patients with malignant melanoma.

Authors: K Palmer; J Moore; M Everard; J D Harris; S Rodgers; R C Rees; A K Murray; R Mascari; J Kirkwood; P G Riches; C Fisher; J M Thomas; M Harries; S R Johnston; M K Collins; M E Gore
Journal: Hum Gene Ther Date: 1999-05-20 Impact factor: 5.695

7. Inverse targeting of retroviral vectors: selective gene transfer in a mixed population of hematopoietic and nonhematopoietic cells.

Authors: A K Fielding; M Maurice; F J Morling; F L Cosset; S J Russell
Journal: Blood Date: 1998-03-01 Impact factor: 22.113

8. Targeting strategy for gene delivery to carcinoembryonic antigen-producing cancer cells by retrovirus displaying a single-chain variable fragment antibody.

Authors: H Konishi; T Ochiya; K A Chester; R H Begent; T Muto; T Sugimura; M Terada; R H Begent
Journal: Hum Gene Ther Date: 1998-01-20 Impact factor: 5.695

Targeted retroviral infection of tumor cells by receptor cooperation.

1. Receptor co-operation in retrovirus entry: recruitment of an auxiliary entry mechanism after retargeted binding.

2. A proline-rich motif downstream of the receptor binding domain modulates conformation and fusogenicity of murine retroviral envelopes.

3. High-titer packaging cells producing recombinant retroviruses resistant to human serum.

4. Generation and selection of monoclonal antibodies, single-chain Fv and antibody fusion phage specific for human melanoma-associated antigens.

5. Selective transduction of protease-rich tumors by matrix-metalloproteinase-targeted retroviral vectors.

6. Gene therapy with autologous, interleukin 2-secreting tumor cells in patients with malignant melanoma.

7. Inverse targeting of retroviral vectors: selective gene transfer in a mixed population of hematopoietic and nonhematopoietic cells.

8. Targeting strategy for gene delivery to carcinoembryonic antigen-producing cancer cells by retrovirus displaying a single-chain variable fragment antibody.

9. Retrovirus targeting by tropism restriction to melanoma cells.

10. Modification of retroviral tropism by display of IGF-I.

1. Rapid adaptation of a recombinant vesicular stomatitis virus to a targeted cell line.

2. Polysaccharide-modified scaffolds for controlled lentivirus delivery in vitro and after spinal cord injury.

Review 3. Library screening and receptor-directed targeting of gammaretroviral vectors.