| Literature DB >> 12551774 |
R P M Steegers-Theunissen, E A P Steegers.
Abstract
It is hypothesized that the following periconceptional and early pregnancy nutrient-gene interactions link vascular-related reproductive complications and cardiovascular diseases in adulthood: (1) Maternal and paternal genetically controlled nutrient status affects the quality of gametes and fertilization capacity; (2) The embryonic genetic constitution, derived from both parents, and the maternal genetically controlled nutrient environment determine embryogenesis and fetal growth; (3) Trophoblast invasion of decidua and spiral arteries is driven by genes derived from both parents as well as by maternal nutritional factors; (4) Angiogenesis, vasculogenesis and vascular function are dependent on the genetic constitution of the embryo, derived from both parents, and the maternal genetically controlled nutritional environment.Early intra-uterine programming of vessels may concern the same (in)dependent determinants of vascular-related complications during pregnancy and cardiovascular diseases in later life.Entities:
Mesh：
Year: 2003 PMID： 12551774 DOI： 10.1016/s0301-2115(02)00358-5
Source DB: PubMed Journal: Eur J Obstet Gynecol Reprod Biol ISSN： 0301-2115 Impact factor: 2.435