Literature DB >> 12549677

New methods in predictive metabolism.

Scott Boyer1, Ismael Zamora.   

Abstract

Mesh：

Year:  2002        PMID： 12549677     DOI： 10.1023/a:1021340717772

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


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  11 in total

1.  Competitive CYP2C9 inhibitors: enzyme inhibition studies, protein homology modeling, and three-dimensional quantitative structure-activity relationship analysis.

Authors:  L Afzelius; I Zamora; M Ridderström; T B Andersson; A Karlén; C M Masimirembwa
Journal:  Mol Pharmacol       Date:  2001-04       Impact factor: 4.436

Review 2.  Systematic LC/MS metabolite identification in drug discovery.

Authors:  N J Clarke; D Rindgen; W A Korfmacher; K A Cox
Journal:  Anal Chem       Date:  2001-08-01       Impact factor: 6.986

3.  GRid-INdependent descriptors (GRIND): a novel class of alignment-independent three-dimensional molecular descriptors.

Authors:  M Pastor; G Cruciani; I McLay; S Pickett; S Clementi
Journal:  J Med Chem       Date:  2000-08-24       Impact factor: 7.446

4.  Predicting the rates and regioselectivity of reactions mediated by the P450 superfamily.

Authors:  J P Jones; K R Korzekwa
Journal:  Methods Enzymol       Date:  1996       Impact factor: 1.600

5.  A computational procedure for determining energetically favorable binding sites on biologically important macromolecules.

Authors:  P J Goodford
Journal:  J Med Chem       Date:  1985-07       Impact factor: 7.446

6.  META. 2. A dictionary model of mammalian xenobiotic metabolism.

Authors:  J Talafous; L M Sayre; J J Mieyal; G Klopman
Journal:  J Chem Inf Comput Sci       Date:  1994 Nov-Dec

7.  Putative active site template model for cytochrome P4502C9 (tolbutamide hydroxylase).

Authors:  B C Jones; G Hawksworth; V A Horne; A Newlands; J Morsman; M S Tute; D A Smith
Journal:  Drug Metab Dispos       Date:  1996-02       Impact factor: 3.922

8.  Analysis of selective regions in the active sites of human cytochromes P450, 2C8, 2C9, 2C18, and 2C19 homology models using GRID/CPCA.

Authors:  M Ridderström; I Zamora; O Fjellström; T B Andersson
Journal:  J Med Chem       Date:  2001-11-22       Impact factor: 7.446

9.  A novel approach to predicting P450 mediated drug metabolism. CYP2D6 catalyzed N-dealkylation reactions and qualitative metabolite predictions using a combined protein and pharmacophore model for CYP2D6.

Authors:  M J de Groot; M J Ackland; V A Horne; A A Alex; B C Jones
Journal:  J Med Chem       Date:  1999-10-07       Impact factor: 7.446

10.  Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity.

Authors:  P A Williams; J Cosme; V Sridhar; E F Johnson; D E McRee
Journal:  Mol Cell       Date:  2000-01       Impact factor: 17.970
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