Literature DB >> 12548011

Are p27 and p21 cytoplasmic oncoproteins?

Mikhail V Blagosklonny1.   

Abstract

By causing cytoplasmic mislocation of p27 and p21, the Akt oncogenic kinase functionally inactivates these nuclear tumor suppressor proteins. Is cytoplasmic localization of p27 and p21 simply equivalent to loss of their function or are new functions acquired in the cytoplasm? Indeed, several lines of evidence suggest that cytoplasmic p27 and p21 may be oncoproteins with antiapoptotic activities.

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Year:  2002        PMID： 12548011     DOI： 10.4161/cc.1.6.262

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  49 in total

1.  CRL2(LRR-1) targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cells.

Authors:  Natalia G Starostina; Jennifer M Simpliciano; Michael A McGuirk; Edward T Kipreos
Journal:  Dev Cell       Date:  2010-11-16       Impact factor: 12.270

2.  Binding of calmodulin to the carboxy-terminal region of p21 induces nuclear accumulation via inhibition of protein kinase C-mediated phosphorylation of Ser153.

Authors:  Aina Rodríguez-Vilarrupla; Montserrat Jaumot; Neus Abella; Núria Canela; Sonia Brun; Carmen Díaz; Josep M Estanyol; Oriol Bachs; Neus Agell
Journal:  Mol Cell Biol       Date:  2005-08       Impact factor: 4.272

3.  Reactive oxygen species and mitochondrial sensitivity to oxidative stress determine induction of cancer cell death by p21.

Authors:  Ionica Masgras; Samantha Carrera; Petra J de Verdier; Paul Brennan; Aneela Majid; Wan Makhtar; Eugene Tulchinsky; George D D Jones; Igor B Roninson; Salvador Macip
Journal:  J Biol Chem       Date:  2012-02-06       Impact factor: 5.157

4.  Involvement of Akt, Ras and cell cycle regulators in the potential development of endometrial hyperplasia in women with polycystic ovarian syndrome.

Authors:  A Villavicencio; A Goyeneche; C Telleria; K Bacallao; F Gabler; A Fuentes; M Vega
Journal:  Gynecol Oncol       Date:  2009-07-23       Impact factor: 5.482

5.  Invadopodia-mediated ECM degradation is enhanced in the G1 phase of the cell cycle.

Authors:  Battuya Bayarmagnai; Louisiane Perrin; Kamyar Esmaeili Pourfarhangi; Xavier Graña; Erkan Tüzel; Bojana Gligorijevic
Journal:  J Cell Sci       Date:  2019-10-18       Impact factor: 5.285

6.  Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization.

Authors:  Maria Letizia Motti; Daniela Califano; Giancarlo Troncone; Carmela De Marco; Ilenia Migliaccio; Emiliano Palmieri; Luciano Pezzullo; Lucio Palombini; Alfredo Fusco; Giuseppe Viglietto
Journal:  Am J Pathol       Date:  2005-03       Impact factor: 4.307

7.  Ciclopirox enhances pancreatic islet health by modulating the unfolded protein response in diabetes.

Authors:  Chrysovalantou Mihailidou; Ioulia Chatzistamou; Athanasios G Papavassiliou; Hippokratis Kiaris
Journal:  Pflugers Arch       Date:  2016-10-19       Impact factor: 3.657

8.  Germline and somatic mutations in cyclin-dependent kinase inhibitor genes CDKN1A, CDKN2B, and CDKN2C in sporadic parathyroid adenomas.

Authors:  Jessica Costa-Guda; Chen-Pang Soong; Vaishali I Parekh; Sunita K Agarwal; Andrew Arnold
Journal:  Horm Cancer       Date:  2013-05-29       Impact factor: 3.869

Review 9.  The function of p27 KIP1 during tumor development.

Authors:  Jinhwa Lee; Sung Soo Kim
Journal:  Exp Mol Med       Date:  2009-11-30       Impact factor: 8.718

10.  Expression and altered subcellular localization of the cyclin-dependent kinase inhibitor p27Kip1 in hepatocellular carcinoma.

Authors:  Ke-Jun Nan; Zhao Jing; Ling Gong
Journal:  World J Gastroenterol       Date:  2004-05-15       Impact factor: 5.742
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