Literature DB >> 12547508

How many lethal alleles?

Daniel L Halligan1, Peter D Keightley.   

Abstract

Knowledge of the frequency of lethal mutant alleles in a population is important for our understanding of population genetics and evolution, and yet there have been few attempts to measure their number in wild populations. A new study has revealed unexpectedly low numbers of segregating lethal alleles in two species of fish. More experiments are needed, however, to know whether this result is general.

Mesh:

Year:  2003        PMID: 12547508     DOI: 10.1016/S0168-9525(02)00045-8

Source DB:  PubMed          Journal:  Trends Genet        ISSN: 0168-9525            Impact factor:   11.639


  4 in total

1.  A high frequency of beneficial mutations across multiple fitness components in Saccharomyces cerevisiae.

Authors:  David W Hall; Sarah B Joseph
Journal:  Genetics       Date:  2010-06-01       Impact factor: 4.562

2.  Comparison of life history characteristics of the genetically modified OX513A line and a wild type strain of Aedes aegypti.

Authors:  Irka Bargielowski; Derric Nimmo; Luke Alphey; Jacob C Koella
Journal:  PLoS One       Date:  2011-06-17       Impact factor: 3.240

3.  An estimate of the average number of recessive lethal mutations carried by humans.

Authors:  Ziyue Gao; Darrel Waggoner; Matthew Stephens; Carole Ober; Molly Przeworski
Journal:  Genetics       Date:  2015-02-18       Impact factor: 4.562

4.  No evidence for accumulation of deleterious mutations and fitness degradation in clonal fish hybrids: Abandoning sex without regrets.

Authors:  Jan Kočí; Jan Röslein; Jan Pačes; Jan Kotusz; Karel Halačka; Ján Koščo; Jakub Fedorčák; Nataliia Iakovenko; Karel Janko
Journal:  Mol Ecol       Date:  2020-08-04       Impact factor: 6.185

  4 in total

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