Literature DB >> 12547503

Ankylosing spondylitis: a beta2m-deposition disease?

Barbara Uchanska-Ziegler1, Andreas Ziegler.   

Abstract

To explain the strong association between HLA-B27 and ankylosing spondylitis, we suggest that the release of beta(2)-microglobulin (beta(2)m) from a subpopulation of cell surface-expressed HLA-B27 molecules leads to beta(2)m-deposition within synovia and to the initiation of an inflammatory process, which culminates in destructive spondyloarthropathy.

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Year:  2003        PMID： 12547503     DOI： 10.1016/s1471-4906(02)00028-5

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  9 in total

1.  Mutational analysis reveals a complex interplay of peptide binding and multiple biological features of HLA-B27.

Authors:  Begoña Galocha; José A López de Castro
Journal:  J Biol Chem       Date:  2010-10-02       Impact factor: 5.157

2.  Natural MHC class I polymorphism controls the pathway of peptide dissociation from HLA-B27 complexes.

Authors:  Kathrin Winkler; Anja Winter; Christine Rueckert; Barbara Uchanska-Ziegler; Ulrike Alexiev
Journal:  Biophys J       Date:  2007-06-15       Impact factor: 4.033

3.  Association of beta2-microglobulin with the alpha3 domain of H-2Db heavy chain.

Authors:  Mirjana Lilić; Zoran Popmihajlov; John J Monaco; Stanislav Vukmanović
Journal:  Immunogenetics       Date:  2004-01-20       Impact factor: 2.846

4.  Multi-modal Binding of a 'Self' Peptide by HLA-B*27:04 and B*27:05 Allelic Variants, but not B*27:09 or B*27:06 Variants: Fresh Support for Some Theories Explaining Differential Disease Association.

Authors:  Manish Kumar Rana; Manni Luthra-Guptasarma
Journal:  Protein J       Date:  2016-10       Impact factor: 2.371

5.  Common immunologic mechanisms in inflammatory bowel disease and spondylarthropathies.

Authors:  Massimo-C Fantini; Francesco Pallone; Giovanni Monteleone
Journal:  World J Gastroenterol       Date:  2009-05-28       Impact factor: 5.742

Review 6.  Role of HLA-B27 in the pathogenesis of ankylosing spondylitis (Review).

Authors:  Bin Chen; Jia Li; Chongru He; Dahe Li; Wenwen Tong; Yuming Zou; Weidong Xu
Journal:  Mol Med Rep       Date:  2017-02-24       Impact factor: 2.952

Review 7.  HLA-C: An Accomplice in Rheumatic Diseases.

Authors:  Ruby J Siegel; S Louis Bridges; Salahuddin Ahmed
Journal:  ACR Open Rheumatol       Date:  2019-09-06

Review 8.  Enteropathic spondyloarthritis: from diagnosis to treatment.

Authors:  Rosario Peluso; Matteo Nicola Dario Di Minno; Salvatore Iervolino; Francesco Manguso; Giuseppina Tramontano; Pasquale Ambrosino; Carmela Esposito; Antonella Scalera; Fabiana Castiglione; Raffaele Scarpa
Journal:  Clin Dev Immunol       Date:  2013-04-15

9.  Dual, HLA-B27 subtype-dependent conformation of a self-peptide.

Authors:  Martin Hülsmeyer; Maria Teresa Fiorillo; Francesca Bettosini; Rosa Sorrentino; Wolfram Saenger; Andreas Ziegler; Barbara Uchanska-Ziegler
Journal:  J Exp Med       Date:  2004-01-19       Impact factor: 14.307
  9 in total

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