BACKGROUND: Rates of remission and relapse were studied over more than 2 years in a sample of Spanish outpatients with DSM-III-R criteria of unipolar major depressive episodes. METHODS: Patients were treated following standardised pharmacological protocols at our centre. In the first visit, the structured clinical interview for DSM-III-R (SCID) was used. The following visits were held monthly. Phases of evolution were recorded using the Hamilton Depression Rating Scale (HDRS), applying the Frank criteria. RESULTS: A significantly greater proportion of relapse was observed in the partial remission group compared to the complete remission one. The rate of relapses for patients in complete remission was 15.18%, while for patients in partial remission was 67.61%. Partial remission was significantly associated with relapses. LIMITATIONS: The short duration of the study and the decreasing sample size during the follow-up. CONCLUSIONS: Partial remission after a depressive episode seems to be strongly associated with relapses. Moreover, this clinical factor could by itself fully predict short-term relapses. CLINICAL RELEVANCE: The study shows the importance of reaching complete remission to decrease the rate of short-term relapses.
BACKGROUND: Rates of remission and relapse were studied over more than 2 years in a sample of Spanish outpatients with DSM-III-R criteria of unipolar major depressive episodes. METHODS:Patients were treated following standardised pharmacological protocols at our centre. In the first visit, the structured clinical interview for DSM-III-R (SCID) was used. The following visits were held monthly. Phases of evolution were recorded using the Hamilton Depression Rating Scale (HDRS), applying the Frank criteria. RESULTS: A significantly greater proportion of relapse was observed in the partial remission group compared to the complete remission one. The rate of relapses for patients in complete remission was 15.18%, while for patients in partial remission was 67.61%. Partial remission was significantly associated with relapses. LIMITATIONS: The short duration of the study and the decreasing sample size during the follow-up. CONCLUSIONS: Partial remission after a depressive episode seems to be strongly associated with relapses. Moreover, this clinical factor could by itself fully predict short-term relapses. CLINICAL RELEVANCE: The study shows the importance of reaching complete remission to decrease the rate of short-term relapses.
Authors: Daniel J Taylor; Heather M Walters; Jeffrey R Vittengl; Steven Krebaum; Robin B Jarrett Journal: J Affect Disord Date: 2009-09-05 Impact factor: 4.839
Authors: Shawn M McClintock; Mustafa M Husain; Stephen R Wisniewski; Andrew A Nierenberg; Jonathan W Stewart; Madhukar H Trivedi; Ian Cook; David Morris; Diane Warden; Augustus John Rush Journal: J Clin Psychopharmacol Date: 2011-04 Impact factor: 3.153
Authors: R Eric Lewandowski; Mary C Acri; Kimberly E Hoagwood; Mark Olfson; Greg Clarke; William Gardner; Sarah Hudson Scholle; Sepheen Byron; Kelly Kelleher; Harold A Pincus; Samantha Frank; Sarah M Horwitz Journal: Pediatrics Date: 2013-09-16 Impact factor: 7.124
Authors: Rachel Manber; Helena C Kraemer; Bruce A Arnow; Madhukar H Trivedi; A John Rush; Michael E Thase; Barbara O Rothbaum; Daniel N Klein; James H Kocsis; Alan J Gelenberg; Martin E Keller Journal: J Consult Clin Psychol Date: 2008-06