Literature DB >> 12547033

Barriers to remember: brain-targeting chemical delivery systems and Alzheimer's disease.

Nicholas Bodor1, Peter Buchwald.   

Abstract

Brain-targeted chemical delivery systems (CDSs) represent rational drug design attempts not only to deliver but also to target drugs to their site of action. Using a sequential metabolism approach, the special bidirectional properties of the blood-brain barrier can be exploited to smuggle the precursors of therapeutic compounds across the barrier and lock them inside the brain ready for sustained release of the active drugs. Many potential therapeutic applications can be envisioned for such CDSs; here, the potential of brain-targeted estradiol for the prevention and treatment of Alzheimer's disease is reviewed in detail.

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Year:  2002        PMID： 12547033     DOI： 10.1016/s1359-6446(02)02332-2

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  10 in total

Review 1.  New technologies for drug delivery across the blood brain barrier.

Authors:  A V Kabanov; E V Batrakova
Journal:  Curr Pharm Des       Date:  2004       Impact factor: 3.116

2.  Size mapping of electric field-assisted production of polycaprolactone particles.

Authors:  M Enayati; Z Ahmad; E Stride; M Edirisinghe
Journal:  J R Soc Interface       Date:  2010-06-02       Impact factor: 4.118

Review 3.  Engineering poly(lactic-co-glycolic acid) (PLGA) micro- and nano-carriers for Controlled Delivery of 17β-Estradiol.

Authors:  Alesia V Prakapenka; Heather A Bimonte-Nelson; Rachael W Sirianni
Journal:  Ann Biomed Eng       Date:  2017-06-20       Impact factor: 3.934

Review 4.  The blood-brain barrier.

Authors:  Felix Dyrna; Sophie Hanske; Martin Krueger; Ingo Bechmann
Journal:  J Neuroimmune Pharmacol       Date:  2013-06-06       Impact factor: 4.147

Review 5.  Prodrug approaches for CNS delivery.

Authors:  Jarkko Rautio; Krista Laine; Mikko Gynther; Jouko Savolainen
Journal:  AAPS J       Date:  2008-02-05       Impact factor: 4.009

6.  Chemical Delivery System of MIBG to the Central Nervous System: Synthesis, 11C-Radiosynthesis, and in Vivo Evaluation.

Authors:  Fabienne Gourand; Delphine Patin; Axelle Henry; Méziane Ibazizène; Martine Dhilly; Fabien Fillesoye; Olivier Tirel; Mihaela-Liliana Tintas; Cyril Papamicaël; Vincent Levacher; Louisa Barré
Journal:  ACS Med Chem Lett       Date:  2019-02-15       Impact factor: 4.345

Review 7.  Single compartment drug delivery.

Authors:  Michael J Cima; Heejin Lee; Karen Daniel; Laura M Tanenbaum; Aikaterini Mantzavinou; Kevin C Spencer; Qunya Ong; Jay C Sy; John Santini; Carl M Schoellhammer; Daniel Blankschtein; Robert S Langer
Journal:  J Control Release       Date:  2014-05-04       Impact factor: 9.776

Review 8.  Nanotechnology Approaches for Enhanced CNS Drug Delivery in the Management of Schizophrenia.

Authors:  Rajalakshmi Rajendran; Krishnakumar Neelakandha Menon; Sreeja Chandrasekharan Nair
Journal:  Adv Pharm Bull       Date:  2021-10-02

Review 9.  Current approaches to enhance CNS delivery of drugs across the brain barriers.

Authors:  Cui-Tao Lu; Ying-Zheng Zhao; Ho Lun Wong; Jun Cai; Lei Peng; Xin-Qiao Tian
Journal:  Int J Nanomedicine       Date:  2014-05-10

10.  In Silico Drug Design of Benzothiadiazine Derivatives Interacting with Phospholipid Cell Membranes.

Authors:  Zheyao Hu; Jordi Marti
Journal:  Membranes (Basel)       Date:  2022-03-17
  10 in total

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