Literature DB >> 12546877

The impact of protein biochips and microarrays on the drug development process.

Christoph Huels1, Stefan Muellner, Helmut E Meyer, Dolores J Cahill.   

Abstract

With the genome sequences of several organisms now in public databases, the scientific community has realized that it is time to prepare for the next step: the understanding of biological systems or systems biology. Whereas genes contain the information for life, the encoded proteins and RNAs fulfill nearly all the functions, from replication to regulation. At present, there is a perceived demand for high-throughput and parallel analytical devices as research tools in systems biology, and, in addition, for new concepts to extract knowledge and value from these data. Protein biochips will play a decisive role in meeting this need in the future.

Mesh:

Year:  2002        PMID: 12546877     DOI: 10.1016/s1359-6446(02)02389-9

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN: 1359-6446            Impact factor:   7.851


  6 in total

1.  Combination of cysteine- and oligomerization domain-mediated protein immobilization on a surface plasmon resonance (SPR) gold chip surface.

Authors:  Kyoungsook Park; Jeong Min Lee; Yongwon Jung; Tsegaye Habtemariam; Abdela Woubit Salah; Cesar D Fermin; Moonil Kim
Journal:  Analyst       Date:  2011-04-26       Impact factor: 4.616

2.  Multiplex mRNA assay using electrophoretic tags for high-throughput gene expression analysis.

Authors:  Huan Tian; Liching Cao; Yuping Tan; Stephen Williams; Lili Chen; Tracy Matray; Ahmed Chenna; Sean Moore; Vincent Hernandez; Vivian Xiao; Mengxiang Tang; Sharat Singh
Journal:  Nucleic Acids Res       Date:  2004-09-08       Impact factor: 16.971

3.  Current awareness on comparative and functional genomics.

Authors: 
Journal:  Comp Funct Genomics       Date:  2003

4.  Amplified RNA degradation in T7-amplification methods results in biased microarray hybridizations.

Authors:  Andrej-Nikolai Spiess; Nadine Mueller; Richard Ivell
Journal:  BMC Genomics       Date:  2003-11-10       Impact factor: 3.969

5.  Data mining for gene networks relevant to poor prognosis in lung cancer via backward-chaining rule induction.

Authors:  Mary E Edgerton; Douglas H Fisher; Lianhong Tang; Lewis J Frey; Zhihua Chen
Journal:  Cancer Inform       Date:  2007-02-10

6.  DNA-Redox Cation Interaction Improves the Sensitivity of an Electrochemical Immunosensor for Protein Detection.

Authors:  Ping Li; Bixia Ge; Lily M-L Ou; Zhihui Yao; Hua-Zhong Yu
Journal:  Sensors (Basel)       Date:  2015-08-20       Impact factor: 3.576

  6 in total

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