Literature DB >> 12546715

Pharmacological actions of Uncaria alkaloids, rhynchophylline and isorhynchophylline.

Jing-Shan Shi1, Jun-Xian Yu, Xiu-Ping Chen, Rui-Xia Xu.   

Abstract

The pharmacological actions of Uncaria alkaloids, rhynchophylline and isorhynchophylline extracted from Uncaria rhynchophylla Miq Jacks were reviewed. The alkaloids mainly act on cardiovascular system and central nervous system including the hypotension, brachycardia, antiarrhythmia, and protection of cerebral ischemia and sedation. The active mechanisms were related to blocking of calcium channel, opening of potassium channel, and regulating of nerve transmitters transport and metabolism, etc.

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Year:  2003        PMID： 12546715

Source DB:  PubMed          Journal:  Acta Pharmacol Sin        ISSN： 1671-4083            Impact factor:   6.150


  28 in total

1.  Rhynchophylline-induced vasodilation in human mesenteric artery is mainly due to blockage of L-type calcium channels in vascular smooth muscle cells.

Authors:  Peng-Yun Li; Xiao-Rong Zeng; Jun Cheng; Jing Wen; Isao Inoue; Yan Yang
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2013-06-30       Impact factor: 3.000

2.  Rhynchophylla total alkaloid rescues autophagy, decreases oxidative stress and improves endothelial vasodilation in spontaneous hypertensive rats.

Authors:  Chao Li; Feng Jiang; Yun-Lun Li; Yue-Hua Jiang; Wen-Qing Yang; Jie Sheng; Wen-Juan Xu; Qing-Jun Zhu
Journal:  Acta Pharmacol Sin       Date:  2017-11-09       Impact factor: 6.150

Review 3.  Active ingredients in Chinese medicines promoting blood circulation as Na+/K+ -ATPase inhibitors.

Authors:  Ronald J Y Chen; Tzyy-rong Jinn; Yi-ching Chen; Tse-yu Chung; Wei-hung Yang; Jason T C Tzen
Journal:  Acta Pharmacol Sin       Date:  2011-02       Impact factor: 6.150

4.  In vitro vasodilator mechanisms of the indole alkaloids rhynchophylline and isorhynchophylline, isolated from the hook of Uncaria rhynchophylla (Miquel).

Authors:  Wen-Bo Zhang; Chang-Xun Chen; Si-Mui Sim; Chiu-Yin Kwan
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-12-11       Impact factor: 3.000

5.  Rhynchophylline Protects Against the Amyloid β-Induced Increase of Spontaneous Discharges in the Hippocampal CA1 Region of Rats.

Authors:  Hui Shao; Ze Mi; Wei-gang Ji; Cheng-huan Zhang; Teng Zhang; Shuan-cheng Ren; Zhi-ru Zhu
Journal:  Neurochem Res       Date:  2015-10-06       Impact factor: 3.996

6.  Traditional used Plants against Cognitive Decline and Alzheimer Disease.

Authors:  Gunter Peter Eckert
Journal:  Front Pharmacol       Date:  2010-12-08       Impact factor: 5.810

7.  Rhynchophylline Protects Cultured Rat Neurons against Methamphetamine Cytotoxicity.

Authors:  Dan Dan Xu; Robin Hoeven; Rong Rong; William Chi-Shing Cho
Journal:  Evid Based Complement Alternat Med       Date:  2012-03-01       Impact factor: 2.629

8.  Rhynchophylline attenuates migraine in trigeminal nucleus caudalis in nitroglycerin-induced rat model by inhibiting MAPK/NF-кB signaling.

Authors:  Tianbao Lai; Liangyi Chen; Xingyu Chen; Jianquan He; Peiyu Lv; Hua Ge
Journal:  Mol Cell Biochem       Date:  2019-08-16       Impact factor: 3.842

Review 9.  The Role of Chinese Herbal Therapy in Methamphetamine Abuse and its Induced Psychiatric Symptoms.

Authors:  Lin Chen; Qin Ru; Qi Xiong; Mei Zhou; Kai Yue; Yuxiang Wu
Journal:  Front Pharmacol       Date:  2021-05-10       Impact factor: 5.810

10.  Systems pharmacology dissection of multi-scale mechanisms of action for herbal medicines in stroke treatment and prevention.

Authors:  Jingxiao Zhang; Yan Li; Xuetong Chen; Yanqiu Pan; Shuwei Zhang; Yonghua Wang
Journal:  PLoS One       Date:  2014-08-05       Impact factor: 3.240
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