Csaba Szabó1. 1. Inotek Pharmaceuticals Corporation, Beverly, MA, USA.
Abstract
OBJECTIVE: To provide an overview of the role of flagellin as an immunostimulatory and proinflammatory factor. DESIGN: A systematic overview of the literature on this subject. SETTING: An office equipped with a computer and Internet access to PubMed. SUBJECTS: MEDLINE citations between 1960 and 2002. MAIN RESULTS: Flagellin, a protein of 40-60 kD, is the principal constituent of the flagellum, a prominent surface structure found in motile bacteria. Recent work reveals that monomeric flagellin, a protein component of flagellated bacteria, can act as a soluble immunostimulatory and proinflammatory factor, activating the immune/inflammatory axis via the toll-like receptor 5-nuclear factor-kappaB axis. Monocytes, macrophages, and intestinal and pulmonary epithelial cells respond to monomeric flagellin at low concentrations. Monomeric flagellin can induce prominent local and systemic immune/inflammatory responses and. CONCLUSIONS: Recognition of the flagellin-toll-like receptor 5 pathway offers novel opportunities for the experimental therapy of various forms of shock, sepsis, and acute respiratory distress syndrome.
OBJECTIVE: To provide an overview of the role of flagellin as an immunostimulatory and proinflammatory factor. DESIGN: A systematic overview of the literature on this subject. SETTING: An office equipped with a computer and Internet access to PubMed. SUBJECTS: MEDLINE citations between 1960 and 2002. MAIN RESULTS: Flagellin, a protein of 40-60 kD, is the principal constituent of the flagellum, a prominent surface structure found in motile bacteria. Recent work reveals that monomeric flagellin, a protein component of flagellated bacteria, can act as a soluble immunostimulatory and proinflammatory factor, activating the immune/inflammatory axis via the toll-like receptor 5-nuclear factor-kappaB axis. Monocytes, macrophages, and intestinal and pulmonary epithelial cells respond to monomeric flagellin at low concentrations. Monomeric flagellin can induce prominent local and systemic immune/inflammatory responses and. CONCLUSIONS: Recognition of the flagellin-toll-like receptor 5 pathway offers novel opportunities for the experimental therapy of various forms of shock, sepsis, and acute respiratory distress syndrome.
Authors: Amin Tahoun; Kirsty Jensen; Yolanda Corripio-Miyar; Sean P McAteer; Alexander Corbishley; Arvind Mahajan; Helen Brown; David Frew; Aude Aumeunier; David G E Smith; Tom N McNeilly; Elizabeth J Glass; David L Gally Journal: Vet Res Date: 2015-02-19 Impact factor: 3.683