Stephen J Duffy1, Joseph A Vita. 1. Heart Centre, The Alfred Hospital and Baker Heart Research Institute, Melbourne, Victoria, Australia. s.duffy@alfred.org.au
Abstract
PURPOSE OF REVIEW: There continues to be considerable interest in the concept that antioxidant therapy may reduce cardiovascular risk. Phenols have antioxidant properties and may be important micronutrients. Epidemiological studies have demonstrated a strong link between phenolic intake and reduced cardiovascular risk, but the mechanism of benefit has not been determined. RECENT FINDINGS: Recent evidence has emerged that a number of phenolic compounds, particularly flavonoids, reverse vascular endothelial dysfunction. The normal endothelium plays a critical role in regulating vascular function, and endothelial dysfunction is associated with increased cardiovascular risk. The present article reviews the links between phenolic intake, endothelial function and cardiovascular risk. SUMMARY: Endothelium-derived nitric oxide bioactivity appears to be increased by supplementation with a number of phenols, and this may explain some of the favourable effects of high phenolic intake seen in epidemiological studies.
PURPOSE OF REVIEW: There continues to be considerable interest in the concept that antioxidant therapy may reduce cardiovascular risk. Phenols have antioxidant properties and may be important micronutrients. Epidemiological studies have demonstrated a strong link between phenolic intake and reduced cardiovascular risk, but the mechanism of benefit has not been determined. RECENT FINDINGS: Recent evidence has emerged that a number of phenolic compounds, particularly flavonoids, reverse vascular endothelial dysfunction. The normal endothelium plays a critical role in regulating vascular function, and endothelial dysfunction is associated with increased cardiovascular risk. The present article reviews the links between phenolic intake, endothelial function and cardiovascular risk. SUMMARY: Endothelium-derived nitric oxide bioactivity appears to be increased by supplementation with a number of phenols, and this may explain some of the favourable effects of high phenolic intake seen in epidemiological studies.
Authors: T Nickel; K Lackermair; J Scherr; A Calatzis; M Vogeser; H Hanssen; G Waidhauser; U Schönermark; H Methe; S Horster; U Wilbert-Lampen; M Halle Journal: J Nutr Health Aging Date: 2016 Impact factor: 4.075
Authors: Javad Sharifi-Rad; Cristina Quispe; Wissam Zam; Manoj Kumar; Susana M Cardoso; Olivia R Pereira; Adedayo O Ademiluyi; Oluwakemi Adeleke; Ana Catarina Moreira; Jelena Živković; Felipe Noriega; Seyed Abdulmajid Ayatollahi; Farzad Kobarfard; Mehrdad Faizi; Miquel Martorell; Natália Cruz-Martins; Monica Butnariu; Iulia Cristina Bagiu; Radu Vasile Bagiu; Mohammed M Alshehri; William C Cho Journal: Oxid Med Cell Longev Date: 2021-08-17 Impact factor: 6.543