| Literature DB >> 12543979 |
Yi Tang1, Varalakshmi Katuri, Allan Dillner, Bibhuti Mishra, Chu-Xia Deng, Lopa Mishra.
Abstract
Disruption of the adaptor protein ELF, a beta-spectrin, leads to disruption of transforming growth factor-beta (TGF-beta) signaling by Smad proteins in mice. Elf-/- mice exhibit a phenotype similar to smad2+/-/smad3+/- mutant mice of midgestational death due to gastrointestinal, liver, neural, and heart defects. We show that TGF-beta triggers phosphorylation and association of ELF with Smad3 and Smad4, followed by nuclear translocation. ELF deficiency results in mislocalization of Smad3 and Smad4 and loss of the TGF-beta-dependent transcriptional response, which could be rescued by overexpression of the COOH-terminal region of ELF. This study reveals an unexpected molecular link between a major dynamic scaffolding protein and a key signaling pathway.Entities:
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Year: 2003 PMID： 12543979 DOI： 10.1126/science.1075994
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728