Literature DB >> 12543553

Synthesis and potential antimetastatic activity of monovalent and divalent beta-D-galactopyranosyl-(1-->4)-2-acetamido-2-deoxy-D-glucopyranosides.

Qing Li1, Bin Su, Hui Li, Xiang-Bao Meng, Meng-Shen Cai, Zhong-Jun Li, Rou-Li Zhou, Ta-Lin Suo.   

Abstract

Anomers of monovalent and divalent beta-D-galactopyranosyl-(1-->4)-2-acetamido-2-deoxy-D-gluco-pyranosides were synthesized under different glycosylation conditions, and evaluated for in vitro antimetastatic activity. Three compounds showed promising inhibitory effects on cancer cell attachment, spreading, migration, and invasion.

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Year:  2003        PMID： 12543553     DOI： 10.1016/s0008-6215(02)00438-x

Source DB:  PubMed          Journal:  Carbohydr Res        ISSN： 0008-6215            Impact factor:   2.104


  2 in total

1.  Lactosyl derivatives function in a rat model of severe burn shock by acting as antagonists against CD11b of integrin on leukocytes.

Authors:  Zhihui Zhao; Qing Li; Jiale Hu; Zhongjun Li; Jinghua Liu; Aihua Liu; Peng Deng; Lin Zhang; Xiaowei Gong; Kesen Zhao; Shuangquan Zhang; Yong Jiang
Journal:  Glycoconj J       Date:  2008-11-20       Impact factor: 2.916

2.  A dual-role of Gu-4 in suppressing HMGB1 secretion and blocking HMGB1 pro-inflammatory activity during inflammation.

Authors:  Huiting Zhou; Xuemei Ji; Yun Wu; Ju Xuan; Zhilin Qi; Lei Shen; Lei Lan; Qing Li; Zhimin Yin; Zhongjun Li; Zhihui Zhao
Journal:  PLoS One       Date:  2014-03-06       Impact factor: 3.240
  2 in total

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