Literature DB >> 12543502

Separation of antifungal chiral drugs by SFC and HPLC: a comparative study.

J L Bernal1, L Toribio, M J del Nozal, E M Nieto, M I Montequi.   

Abstract

The enantiomeric separation of several compounds, including an antifungal drug and several of its precursors, using HPLC and SFC is described in this work. The columns employed were based on polysaccharide derivatives and the results show that most of the separations obtained by SFC are better, in terms of high resolution and short analysis time, than those obtained by HPLC. Only one compound could not be resolved using SFC but, in this case, HPLC provided baseline resolution. Copyright 2002 Elsevier Science B.V.

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Year:  2002        PMID: 12543502     DOI: 10.1016/s0165-022x(02)00119-7

Source DB:  PubMed          Journal:  J Biochem Biophys Methods        ISSN: 0165-022X


  1 in total

1.  Improved Chiral Separation of (R,S)-Goitrin by SFC: An Application in Traditional Chinese Medicine.

Authors:  Lixing Nie; Zhong Dai; Shuangcheng Ma
Journal:  J Anal Methods Chem       Date:  2016-02-21       Impact factor: 2.193

  1 in total

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