OBJECTIVE: Patients with familial hypercholesterolaemia (FH) vary widely in terms of onset of cardiovascular disease (CVD). DESIGN: The association between cardiovascular risk factors and prevalent CVD was examined in a cross-sectional study in order to elucidate their contribution to atherogenesis. SETTING AND SUBJECTS: Patients were recruited from 37 Dutch Lipid Clinics. The diagnosis of FH was based on a uniform diagnostic protocol, confirmed by DNA analysis in 62% of the cases. All patients were investigated free from any lipid-lowering drug for at least 6 weeks. MAIN OUTCOME MEASURES: Differences in lipids, lipoproteins and other risk factors for CVD were analysed in FH patients with and without CVD. RESULTS: A total of 526 patients were assessed and more than 37% had a history of CVD with a mean age of onset of 46.8 years. Mean LDL cholesterol (LDL-C) levels were severely elevated (8.38 +/- 2.13 mmol L-1). In univariate analysis, age, presence of hypertension or diabetes, body mass index, triglycerides (TG) and low HDL cholesterol (HDL-C) were all significantly associated with CVD. Also in multivariate analysis, all these risk factors, except TG and diabetes, were significantly linked to CVD. CONCLUSION: A high CVD risk in this large well-documented characterized sample of FH patients is not only conferred by elevated LDL-C but also by low HDL-C.
OBJECTIVE:Patients with familial hypercholesterolaemia (FH) vary widely in terms of onset of cardiovascular disease (CVD). DESIGN: The association between cardiovascular risk factors and prevalent CVD was examined in a cross-sectional study in order to elucidate their contribution to atherogenesis. SETTING AND SUBJECTS:Patients were recruited from 37 Dutch Lipid Clinics. The diagnosis of FH was based on a uniform diagnostic protocol, confirmed by DNA analysis in 62% of the cases. All patients were investigated free from any lipid-lowering drug for at least 6 weeks. MAIN OUTCOME MEASURES: Differences in lipids, lipoproteins and other risk factors for CVD were analysed in FHpatients with and without CVD. RESULTS: A total of 526 patients were assessed and more than 37% had a history of CVD with a mean age of onset of 46.8 years. Mean LDL cholesterol (LDL-C) levels were severely elevated (8.38 +/- 2.13 mmol L-1). In univariate analysis, age, presence of hypertension or diabetes, body mass index, triglycerides (TG) and low HDL cholesterol (HDL-C) were all significantly associated with CVD. Also in multivariate analysis, all these risk factors, except TG and diabetes, were significantly linked to CVD. CONCLUSION: A high CVD risk in this large well-documented characterized sample of FHpatients is not only conferred by elevated LDL-C but also by low HDL-C.
Authors: H A W Neil; V Seagroatt; D J Betteridge; M P Cooper; P N Durrington; J P Miller; M Seed; R P Naoumova; G R Thompson; R Huxley; S E Humphries Journal: Heart Date: 2004-12 Impact factor: 5.994
Authors: Juan Criado-García; Francisco Fuentes; Cristina Cruz-Teno; Antonio García-Rios; Anabel Jiménez-Morales; Javier Delgado-Lista; Pedro Mata; Rodrigo Alonso; José López-Miranda; Francisco Pérez-Jiménez Journal: Lipids Health Dis Date: 2011-04-09 Impact factor: 3.876
Authors: S E Humphries; R A Whittall; C S Hubbart; S Maplebeck; J A Cooper; A K Soutar; R Naoumova; G R Thompson; M Seed; P N Durrington; J P Miller; D J B Betteridge; H A W Neil Journal: J Med Genet Date: 2006-12 Impact factor: 6.318