Literature DB >> 12542402

Molecular targets in breast cancer: current status and future directions.

M Cristofanilli1, G N Hortobagyi.   

Abstract

Our increasing understanding of the pathophysiologic mechanisms of breast carcinogenesis has generated detailed information about the potential roles of specific biomolecular markers in this process. Furthermore, in the last few years the process of targeted drug design has become faster and more sophisticated, providing a variety of agents targeted at these molecules. In this review, we describe the most widely recognized molecular targets in breast cancer.

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Year:  2002        PMID: 12542402     DOI: 10.1677/erc.0.0090249

Source DB:  PubMed          Journal:  Endocr Relat Cancer        ISSN: 1351-0088            Impact factor:   5.678


  4 in total

1.  Structure-activity relationship of conformationally constrained peptidomimetics for antiproliferative activity in HER2-overexpressing breast cancer cell lines.

Authors:  Sashikanth Banappagari; Sharon Ronald; Seetharama D Satyanarayanajois
Journal:  Medchemcomm       Date:  2011-01-01       Impact factor: 3.597

2.  A conformationally constrained peptidomimetic binds to the extracellular region of HER2 protein.

Authors:  Sashikanth Banappagari; Sharon Ronald; Seetharama D Satyanarayanajois
Journal:  J Biomol Struct Dyn       Date:  2010-12

3.  Cancer-relevant biochemical targets of cytotoxic Lonchocarpus flavonoids: a molecular docking analysis.

Authors:  Caitlin E Cassidy; William N Setzer
Journal:  J Mol Model       Date:  2009-07-15       Impact factor: 1.810

4.  Design, synthesis, and docking studies of peptidomimetics based on HER2-herceptin binding site with potential antiproliferative activity against breast cancer cell lines.

Authors:  Seetharama Satyanarayanajois; Stephanie Villalba; Liu Jianchao; Go Mei Lin
Journal:  Chem Biol Drug Des       Date:  2009-09       Impact factor: 2.817

  4 in total

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