| Literature DB >> 12542368 |
Mamadou Bocar1, Akino Jossang, Bernard Bodo.
Abstract
Four new cephalotaxus alkaloids, cephalotaxine alpha-N-oxide (1), cephalotaxine beta-N-oxide (2), 11-beta-hydroxycephalotaxine beta-N-oxide (3), and isocephalotaxine (4), were isolated, together with several known alkaloids from an EtOAc extract of the fruits of Cephalotaxus fortunei. The structures were determined by spectral analysis including mass spectrometry and 2D NMR. Compounds 1, 2, 3, and 4 displayed cytotoxicity against nasopharynx KB cells with IC50 values of 30, 14, 31, and 15 micro g/mL, respectively.Entities:
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Year: 2003 PMID： 12542368 DOI： 10.1021/np0203178
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050