Literature DB >> 12542364

A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).

Giovanni Appendino1, Carla Della Porta, Gwenaëlle Conseil, Olov Sterner, Enrico Mercalli, Charles Dumontet, Attilio Di Pietro.   

Abstract

The macrocyclic lathyrane polyester Euphorbia factor L10 (1a) has been obtained from the seeds of the caper spurge (E. lathyris). The interaction of L10 (1a) and its acetyl derivative (1b) with P-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. The results established lathyrane diterpenoids as a novel chemotype for P-glycoprotein inhibitors.

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Year:  2003        PMID： 12542364     DOI： 10.1021/np0203537

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  9 in total

Review 1.  Efflux transporters as a novel herbivore countermechanism to plant chemical defenses.

Authors:  Jennifer S Sorensen; M Denise Dearing
Journal:  J Chem Ecol       Date:  2006-05-23       Impact factor: 2.626

Review 2.  Application of pharmacological approaches to plant-mammal interactions.

Authors:  Jennifer S Sorensen; Michele M Skopec; M Denise Dearing
Journal:  J Chem Ecol       Date:  2006-05-23       Impact factor: 2.626

3.  Is alpha-pinene a substrate for permeability-glycoprotein in wood rats?

Authors:  Adam K Green; Shannon L Haley; David M Barnes; M Denise Dearing; William H Karasov
Journal:  J Chem Ecol       Date:  2006-05-23       Impact factor: 2.626

4.  Oxidation and cyclization of casbene in the biosynthesis of Euphorbia factors from mature seeds of Euphorbia lathyris L.

Authors:  Dan Luo; Roberta Callari; Britta Hamberger; Sileshi Gizachew Wubshet; Morten T Nielsen; Johan Andersen-Ranberg; Björn M Hallström; Federico Cozzi; Harald Heider; Birger Lindberg Møller; Dan Staerk; Björn Hamberger
Journal:  Proc Natl Acad Sci U S A       Date:  2016-08-09       Impact factor: 11.205

Review 5.  P-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers: A review.

Authors:  Hossam M Abdallah; Ahmed M Al-Abd; Riham Salah El-Dine; Ali M El-Halawany
Journal:  J Adv Res       Date:  2014-12-01       Impact factor: 10.479

6.  Analysis and determination of diterpenoids in unprocessed and processed Euphorbia lathyris seeds by HPLC-ESI-MS.

Authors:  Xiao-Rong Hou; Lei-Lei Wan; Zha-Jun Zhan; Cheng-Ping Li; Wei-Guang Shan
Journal:  J Pharm Anal       Date:  2011-07-30

7.  Characterization of the complete chloroplast genome of Euphorbia lathyris (Euphorbiaceae), a traditional Chinese medicine.

Authors:  Xueyan Zhao; Qing Wang; Fangyuan Wang; Yan Li
Journal:  Mitochondrial DNA B Resour       Date:  2020-05-20       Impact factor: 0.658

Review 8.  Pharmacological Potential of Lathyrane-Type Diterpenoids from Phytochemical Sources.

Authors:  Fátima Vela; Abdellah Ezzanad; Alan Christy Hunter; Antonio José Macías-Sánchez; Rosario Hernández-Galán
Journal:  Pharmaceuticals (Basel)       Date:  2022-06-23

9.  Mechanism of action of cytotoxic compounds from the seeds of Euphorbia lathyris.

Authors:  Yu-Ning Teng; Yingzi Wang; Pei-Ling Hsu; Guang Xin; Yu Zhang; Susan L Morris-Natschke; Masuo Goto; Kuo-Hsiung Lee
Journal:  Phytomedicine       Date:  2018-02-02       Impact factor: 5.340
  9 in total

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