H Nong1, J Li, G Huang, D Nong, P Cheng, C Yao. 1. Otolaryngology of First Affiliated Hospital of Guangxi Medical University, Nanning 530021.
Abstract
OBJECTIVE: To study otomycosis of pathogenic fungi, antifungal susceptibility test and clinical efficacy. METHOD: The study was performed as follows: 1) culture of pathogenic fungi and fungus identification in 110 cases. 2) antifungal susceptibility test with Etest strip by ketoconazole (KE), itraconazole (IT), Fluconazole (FC), Fluorocytosine (FL), and amphotericinum B (AP). 3) Topical application of doktarin ps cream (DC), ketoconazole cream (KEC), clotrimazole ung (CU), and thymol alcohol (TA) were performed in 4 groups and the intermittent impulsive treatment in who failed to respond to local treatment were performed too. RESULT AND CONCLUSION: 1) Chiefly, otomycosis of pathogenic fungi were aspergillus (79%) and candida albicans (8%) and penicillium citrinum (5%). 2) Antifungal susceptibility test showed that aspergillus were sensitive to KE and IT, but not sensitive to KE and FL, and candida albicans were sensitive to KE, IT, FC, FL and AP all; P. citrinum was sensitive to AP, FL and KE but not to FC. 3) Effective rate of topical application on 4 groups were 97.6%, 97.5%, 90.0% and 80.0% respectively. Comparing the results between compound azoles drugs and TA, there was a statistical significant difference (P < 0.05), the efficacy of compound azoles is better than that of TA. The effective rate of systematic intermittent impulsive treatment in 30 cases failed to respond to local treatment were 100%.
RCT Entities:
OBJECTIVE: To study otomycosis of pathogenic fungi, antifungal susceptibility test and clinical efficacy. METHOD: The study was performed as follows: 1) culture of pathogenic fungi and fungus identification in 110 cases. 2) antifungal susceptibility test with Etest strip by ketoconazole (KE), itraconazole (IT), Fluconazole (FC), Fluorocytosine (FL), and amphotericinum B (AP). 3) Topical application of doktarin ps cream (DC), ketoconazole cream (KEC), clotrimazole ung (CU), and thymol alcohol (TA) were performed in 4 groups and the intermittent impulsive treatment in who failed to respond to local treatment were performed too. RESULT AND CONCLUSION: 1) Chiefly, otomycosis of pathogenic fungi were aspergillus (79%) and candida albicans (8%) and penicillium citrinum (5%). 2) Antifungal susceptibility test showed that aspergillus were sensitive to KE and IT, but not sensitive to KE and FL, and candida albicans were sensitive to KE, IT, FC, FL and AP all; P. citrinum was sensitive to AP, FL and KE but not to FC. 3) Effective rate of topical application on 4 groups were 97.6%, 97.5%, 90.0% and 80.0% respectively. Comparing the results between compound azoles drugs and TA, there was a statistical significant difference (P < 0.05), the efficacy of compound azoles is better than that of TA. The effective rate of systematic intermittent impulsive treatment in 30 cases failed to respond to local treatment were 100%.