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Literature DB >> 12540919

The double helix and immunology.

Abstract

The immune system can recognize and produce antibodies to virtually any molecule in the Universe. This enormous diversity arises from the ingenious reshuffling of DNA sequences encoding components of the immune system. Immunology is an example of a field completely transformed during the past 50 years by the discovery of the structure of DNA and the emergence of DNA technologies that followed.

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Year: 2003 PMID： 12540919 DOI： 10.1038/nature01409

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

7 in total

1. On the conservative nature of intragenic recombination.

Authors: D Allan Drummond; Jonathan J Silberg; Michelle M Meyer; Claus O Wilke; Frances H Arnold
Journal: Proc Natl Acad Sci U S A Date: 2005-04-04 Impact factor: 11.205

2. Chromatin architecture near a potential 3' end of the igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites.

Authors: Francine E Garrett; Alexander V Emelyanov; Manuel A Sepulveda; Patrick Flanagan; Sabrina Volpi; Fubin Li; Dmitry Loukinov; Laurel A Eckhardt; Victor V Lobanenkov; Barbara K Birshtein
Journal: Mol Cell Biol Date: 2005-02 Impact factor: 4.272

3. The CDR-H3 repertoire from TdT-deficient adult bone marrow is a close, but not exact, homologue of the CDR-H3 repertoire from perinatal liver.

Authors: Robert L Schelonka; Ivaylo I Ivanov; Andre M Vale; Ewa Szymanska; Michael Zemlin; G Larry Gartland; Harry W Schroeder
Journal: J Immunol Date: 2010-10-18 Impact factor: 5.422

The double helix and immunology.

1. On the conservative nature of intragenic recombination.

2. Chromatin architecture near a potential 3' end of the igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites.

3. The CDR-H3 repertoire from TdT-deficient adult bone marrow is a close, but not exact, homologue of the CDR-H3 repertoire from perinatal liver.

4. Heterosubtypic immunity to influenza A virus infection requires a properly diversified antibody repertoire.

Review 5. On being the right size: antibody repertoire formation in the mouse and human.

6. Molecular characterization of the feline T-cell receptor γ alternate reading frame protein (TARP) ortholog.

7. Absence of N addition facilitates B cell development, but impairs immune responses.