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Literature DB >> 12540585

Migration through the extracellular matrix by the parasitic protozoan Leishmania is enhanced by surface metalloprotease gp63.

Bradford S McGwire¹, Kwang-Poo Chang, David M Engman.

Abstract

Leishmania species engineered to express high levels of the surface metalloprotease gp63 have enhanced capacity of migration through extracellular matrix in vitro. This correlates with gp63 degradation of extracellular matrix components, such as collagen type IV and fibronectin, and suggests an important role for gp63 in the pathogenesis of leishmaniasis.

Entities: Disease Gene

Mesh：

Substances：

Year: 2003 PMID： 12540585 PMCID： PMC145380 DOI： 10.1128/IAI.71.2.1008-1010.2003

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

16 in total

1. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

Authors: Q Yu; I Stamenkovic
Journal: Genes Dev Date: 2000-01-15 Impact factor: 11.361

2. Interaction of Leishmania gp63 with cellular receptors for fibronectin.

Authors: A Brittingham; G Chen; B S McGwire; K P Chang; D M Mosser
Journal: Infect Immun Date: 1999-09 Impact factor: 3.441

3. Isolation of a laminin-binding protein from the protozoan parasite Leishmania donovani that may mediate cell adhesion.

Authors: A Ghosh; K Bandyopadhyay; L Kole; P K Das
Journal: Biochem J Date: 1999-02-01 Impact factor: 3.857

4. Posttranslational regulation of a Leishmania HEXXH metalloprotease (gp63). The effects of site-specific mutagenesis of catalytic, zinc binding, N-glycosylation, and glycosyl phosphatidylinositol addition sites on N-terminal end cleavage, intracellular stability, and extracellular exit.

Authors: B S McGwire; K P Chang
Journal: J Biol Chem Date: 1996-04-05 Impact factor: 5.157

5. Monoclonal antibody affinity purification of a Leishmania membrane glycoprotein and its inhibition of leishmania-macrophage binding.

Authors: C S Chang; K P Chang
Journal: Proc Natl Acad Sci U S A Date: 1986-01 Impact factor: 11.205

6. Genetic rescue of surface metalloproteinase (gp63)-deficiency in Leishmania amazonensis variants increases their infection of macrophages at the early phase.

Authors: B McGwire; K P Chang
Journal: Mol Biochem Parasitol Date: 1994-08 Impact factor: 1.759

7. Extracellular release of the glycosylphosphatidylinositol (GPI)-linked Leishmania surface metalloprotease, gp63, is independent of GPI phospholipolysis: implications for parasite virulence.

Authors: Bradford S McGwire; William A O'Connell; Kwang-Poo Chang; David M Engman
Journal: J Biol Chem Date: 2002-01-02 Impact factor: 5.157

8. High affinity binding between laminin and laminin binding protein of Leishmania is stimulated by zinc and may involve laminin zinc-finger like sequences.

Authors: Keya Bandyopadhyay; Sudipan Karmakar; Abhijit Ghosh; Pijush K Das
Journal: Eur J Biochem Date: 2002-03

9. Acid protease activity of a major surface membrane glycoprotein (gp63) from Leishmania mexicana promastigotes.

Authors: G Chaudhuri; K P Chang
Journal: Mol Biochem Parasitol Date: 1988-01-01 Impact factor: 1.759

10. Role of the Leishmania surface protease gp63 in complement fixation, cell adhesion, and resistance to complement-mediated lysis.

Authors: A Brittingham; C J Morrison; W R McMaster; B S McGwire; K P Chang; D M Mosser
Journal: J Immunol Date: 1995-09-15 Impact factor: 5.422

40 in total

1. Characterization of metalloproteases and serine proteases of Toxoplasma gondii tachyzoites and their effect on epithelial cells.

Authors: Carlos J Ramírez-Flores; Rosalba Cruz-Mirón; Rossana Arroyo; Mónica E Mondragón-Castelán; Tais Nopal-Guerrero; Sirenia González-Pozos; Emmanuel Ríos-Castro; Ricardo Mondragón-Flores
Journal: Parasitol Res Date: 2018-12-01 Impact factor: 2.289

2. Infection of retinal epithelial cells with L. amazonensis impacts in extracellular matrix proteins.

Authors: Kátia da Silva Calabrese; Leandro de Souza Silva; Luiz Otávio Pereira Carvalho; Daiana de Jesus Hardoim; Mariana da Silva-Almeida; Renato Arruda Mortara; Celeste da Silva Freitas de Souza
Journal: Parasitol Res Date: 2011-04-15 Impact factor: 2.289

3. Internal and surface-localized major surface proteases of Leishmania spp. and their differential release from promastigotes.

Authors: Chaoqun Yao; John E Donelson; Mary E Wilson
Journal: Eukaryot Cell Date: 2007-08-10

Migration through the extracellular matrix by the parasitic protozoan Leishmania is enhanced by surface metalloprotease gp63.

1. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

2. Interaction of Leishmania gp63 with cellular receptors for fibronectin.

3. Isolation of a laminin-binding protein from the protozoan parasite Leishmania donovani that may mediate cell adhesion.

4. Posttranslational regulation of a Leishmania HEXXH metalloprotease (gp63). The effects of site-specific mutagenesis of catalytic, zinc binding, N-glycosylation, and glycosyl phosphatidylinositol addition sites on N-terminal end cleavage, intracellular stability, and extracellular exit.

5. Monoclonal antibody affinity purification of a Leishmania membrane glycoprotein and its inhibition of leishmania-macrophage binding.

6. Genetic rescue of surface metalloproteinase (gp63)-deficiency in Leishmania amazonensis variants increases their infection of macrophages at the early phase.

7. Extracellular release of the glycosylphosphatidylinositol (GPI)-linked Leishmania surface metalloprotease, gp63, is independent of GPI phospholipolysis: implications for parasite virulence.

8. High affinity binding between laminin and laminin binding protein of Leishmania is stimulated by zinc and may involve laminin zinc-finger like sequences.

9. Acid protease activity of a major surface membrane glycoprotein (gp63) from Leishmania mexicana promastigotes.

10. Role of the Leishmania surface protease gp63 in complement fixation, cell adhesion, and resistance to complement-mediated lysis.

1. Characterization of metalloproteases and serine proteases of Toxoplasma gondii tachyzoites and their effect on epithelial cells.

2. Infection of retinal epithelial cells with L. amazonensis impacts in extracellular matrix proteins.

3. Internal and surface-localized major surface proteases of Leishmania spp. and their differential release from promastigotes.

4. Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil: role of COL1A1.

5. Design of protease-resistant pexiganan enhances antileishmanial activity.

6. Hepatic extracellular matrix alterations in dogs naturally infected with Leishmania (Leishmania) chagasi.

7. Fibronectin binding and proteolytic degradation by Leishmania and effects on macrophage activation.

8. The major surface protease (MSP or GP63) in the intracellular amastigote stage of Leishmania chagasi.

Review 9. Major surface protease of trypanosomatids: one size fits all?

10. Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses.