Literature DB >> 12540233

3'-Aminoadenosine-5'-uronamides: discovery of the first highly selective agonist at the human adenosine A3 receptor.

Michael P DeNinno1, Hiroko Masamune, Lois K Chenard, Kenneth J DiRico, Cynthia Eller, John B Etienne, Jeanene E Tickner, Scott P Kennedy, Delvin R Knight, Jimmy Kong, Joseph J Oleynek, W Ross Tracey, Roger J Hill.   

Abstract

Selective adenosine A(3) agonists have potential utility for the prevention of perioperative myocardial ischemic injury. Herein, we report on the discovery and synthesis of compound 7. This amino nucleoside agonist possesses unprecedented levels of selectivity for the human adenosine A(3) receptor.

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Year:  2003        PMID： 12540233     DOI： 10.1021/jm0255724

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  18 in total

1.  Chapter 13. A3 Adenosine Receptors.

Authors:  Kenneth A Jacobson; Susanna Tchilibon; Bhalchandra V Joshi; Zhan-Guo Gao
Journal:  Annu Rep Med Chem       Date:  2003       Impact factor: 1.059

2.  Exploring human adenosine A3 receptor complementarity and activity for adenosine analogues modified in the ribose and purine moiety.

Authors:  Philippe Van Rompaey; Kenneth A Jacobson; Ariel S Gross; Zhan-Guo Gao; Serge Van Calenbergh
Journal:  Bioorg Med Chem       Date:  2005-02-15       Impact factor: 3.641

3.  Synthesis of 3'-acetamidoadenosine derivatives as potential A3 adenosine receptor agonists.

Authors:  Moon Woo Chun; Sung Wook Choi; Tae Kyung Kang; Won Jun Choi; Hea Ok Kim; Zhan-Guo Gao; Kenneth A Jacobson; Lak Shin Jeong
Journal:  Nucleosides Nucleotides Nucleic Acids       Date:  2008-04       Impact factor: 1.381

Review 4.  Medicinal chemistry of the A3 adenosine receptor: agonists, antagonists, and receptor engineering.

Authors:  Kenneth A Jacobson; Athena M Klutz; Dilip K Tosh; Andrei A Ivanov; Delia Preti; Pier Giovanni Baraldi
Journal:  Handb Exp Pharmacol       Date:  2009

5.  Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.

Authors:  Artem Melman; Zhan-Guo Gao; Deepmala Kumar; Tina C Wan; Elizabeth Gizewski; John A Auchampach; Kenneth A Jacobson
Journal:  Bioorg Med Chem Lett       Date:  2008-04-04       Impact factor: 2.823

6.  Ability of CP-532,903 to protect mouse hearts from ischemia/reperfusion injury is dependent on expression of A3 adenosine receptors in cardiomyoyctes.

Authors:  Tina C Wan; Akihito Tampo; Wai-Meng Kwok; John A Auchampach
Journal:  Biochem Pharmacol       Date:  2019-01-30       Impact factor: 5.858

7.  Regio- and stereoselective synthesis of truncated 3'-aminocarbanucleosides and their binding affinity at the A3 adenosine receptor.

Authors:  Mun Ju Choi; Girish Chandra; Hyuk Woo Lee; Xiyan Hou; Won Jun Choi; Khai Phan; Kenneth A Jacobson; Lak Shin Jeong
Journal:  Org Biomol Chem       Date:  2011-08-23       Impact factor: 3.876

8.  (N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists.

Authors:  Susanna Tchilibon; Bhalchandra V Joshi; Soo-Kyung Kim; Heng T Duong; Zhan-Guo Gao; Kenneth A Jacobson
Journal:  J Med Chem       Date:  2005-03-24       Impact factor: 7.446

9.  Modulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position.

Authors:  Michihiro Ohno; Zhan-Guo Gao; Philippe Van Rompaey; Susanna Tchilibon; Soo-Kyung Kim; Brian A Harris; Ariel S Gross; Heng T Duong; Serge Van Calenbergh; Kenneth A Jacobson
Journal:  Bioorg Med Chem       Date:  2004-06-01       Impact factor: 3.641

10.  2-Substituted adenosine derivatives: affinity and efficacy at four subtypes of human adenosine receptors.

Authors:  Zhan-Guo Gao; Liaman K Mamedova; Peiran Chen; Kenneth A Jacobson
Journal:  Biochem Pharmacol       Date:  2004-11-15       Impact factor: 5.858
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