| Literature DB >> 12539572 |
C Zhu1, H Tian, Z Xiong, H Xia.
Abstract
In order to study the fate of human follicle-stimulating hormone (FSH) when hormone binds to its receptor, a quick biochemical method that can differentiate between the surface-bound and internalized hormone was used to determine the internalization induced by FSH in cultured both porcine granulosa cells and Chinese hamster ovary (CHO) cells expressing recombinant porcine FSH receptor. The results showed that FSH was slowly internalized, and the internalized radioactivity (acid resistant) reached a peak 10-12 h after addition of 125I-hFSH. It was suggested that FSHR do not get internalized rapidly under physiological circumstances precisely because the appropriate sequences are absent.Entities:
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Year: 2001 PMID： 12539572 DOI： 10.1007/BF02886425
Source DB: PubMed Journal: J Tongji Med Univ ISSN： 0257-716X