Literature DB >> 12539219

Secondary progressive chronic manganism associated with markedly decreased striatal D2 receptor density.

Kirn R Kessler1, Gilbert Wunderlich, Harald Hefter, Rüdiger J Seitz.   

Abstract

We describe a patient with chronic manganism due to intoxication 40 years ago. Whereas previous reports on acute or subacute intoxication have shown no or only small reductions in striatal D2 receptor density, we found markedly decreased D2 receptor density using (18)F-methylspiperone PET in this very late stage of chronic manganism, supporting the hypothesis that manganese intoxication may trigger a neurodegenerative disease process. Copyright 2002 Movement Disorder Society

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Year:  2003        PMID： 12539219     DOI： 10.1002/mds.10325

Source DB:  PubMed          Journal:  Mov Disord        ISSN： 0885-3185            Impact factor:   10.338


  16 in total

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Authors:  Michael Aschner; Keith M Erikson; Elena Herrero Hernández; Elena Herrero Hernández; Ronald Tjalkens
Journal:  Neuromolecular Med       Date:  2009       Impact factor: 3.843

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Journal:  Neuromolecular Med       Date:  2009-09-16       Impact factor: 3.843

4.  Gender and manganese exposure interactions on mouse striatal neuron morphology.

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Authors:  Cynthia H Kern; Gregg D Stanwood; Donald R Smith
Journal:  Synapse       Date:  2010-05       Impact factor: 2.562

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8.  BDNF and Huntingtin protein modifications by manganese: implications for striatal medium spiny neuron pathology in manganese neurotoxicity.

Authors:  Kirstie H Stansfield; Terry Jo Bichell; Aaron B Bowman; Tomás R Guilarte
Journal:  J Neurochem       Date:  2014-09-02       Impact factor: 5.372

Review 9.  Manganese and Parkinson's disease: a critical review and new findings.

Authors:  Tomás R Guilarte
Journal:  Environ Health Perspect       Date:  2010-04-19       Impact factor: 9.031

10.  Melatonin inhibits manganese-induced motor dysfunction and neuronal loss in mice: involvement of oxidative stress and dopaminergic neurodegeneration.

Authors:  Yu Deng; Congcong Jiao; Chao Mi; Bin Xu; Yuehui Li; Fei Wang; Wei Liu; Zhaofa Xu
Journal:  Mol Neurobiol       Date:  2014-06-28       Impact factor: 5.590
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