Literature DB >> 12539043

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.

Hiroyuki Oshiumi1, Misako Matsumoto, Kenji Funami, Takashi Akazawa, Tsukasa Seya.   

Abstract

Human Toll-like receptor (TLR) 3 recognizes double-stranded (ds) RNA and induces production of interferon (IFN)-beta independent of the adaptor molecules MyD88 and TIRAP. Thus, another adaptor must exist that preferentially mediates TLR3-dependent production of IFN-beta. We have identified an alternative adaptor, designated Toll-interleukin 1 receptor domain (TIR)-containing adaptor molecule (TICAM)-1, that can physically bind the TIR domain of TLR3 and activate the IFN-beta promoter in response to poly(I):poly(C). Thus, dsRNA-TLR3-dependent production of IFN-beta is mediated mainly by TICAM-1. This TICAM-1-dependent pathway may have a role in other TLR-IFN-beta pathways, which form part of the MyD88-independent cellular immune response.

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Year:  2003        PMID： 12539043     DOI： 10.1038/ni886

Source DB:  PubMed          Journal:  Nat Immunol        ISSN： 1529-2908            Impact factor:   25.606


  360 in total

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4.  Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates.

Authors:  Manyi Yang; Shaochun Yuan; Shengfeng Huang; Jun Li; Liqun Xu; Huiqing Huang; Xin Tao; Jian Peng; Anlong Xu
Journal:  Cell Res       Date:  2011-09-20       Impact factor: 25.617

5.  Expression profiling via novel multiplex assay allows rapid assessment of gene regulation in defined signalling pathways.

Authors:  Eric Eldering; C Arnold Spek; Hella L Aberson; Annette Grummels; Ingrid A Derks; Alex F de Vos; Cathal J McElgunn; Jan P Schouten
Journal:  Nucleic Acids Res       Date:  2003-12-01       Impact factor: 16.971

6.  Mycobacterium bovis BCG cell wall-specific differentially expressed genes identified by differential display and cDNA subtraction in human macrophages.

Authors:  Nasim A Begum; Kazuo Ishii; Mitsue Kurita-Taniguchi; Masako Tanabe; Mika Kobayashi; Yasuhiro Moriwaki; Misako Matsumoto; Yasuo Fukumori; Ichiro Azuma; Kumao Toyoshima; Tsukasa Seya
Journal:  Infect Immun       Date:  2004-02       Impact factor: 3.441

7.  Toll-like receptor ligands directly promote activated CD4+ T cell survival.

Authors:  Andrew E Gelman; Jidong Zhang; Yongwon Choi; Laurence A Turka
Journal:  J Immunol       Date:  2004-05-15       Impact factor: 5.422

Review 8.  Innate sensing of viruses by toll-like receptors.

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Journal:  J Virol       Date:  2004-08       Impact factor: 5.103

Review 9.  Into the eye of the cytokine storm.

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Review 10.  Deciphering the complexity of Toll-like receptor signaling.

Authors:  Renato Ostuni; Ivan Zanoni; Francesca Granucci
Journal:  Cell Mol Life Sci       Date:  2010-07-31       Impact factor: 9.261
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