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Literature DB >> 12538858

The role of nuclear factor-kappaB essential modulator (NEMO) in B cell development and survival.

Shinyop Kim¹, Ross N A La Motte-Mohs, Dorothea Rudolph, Juan Carlos Zuniga-Pflucker, Tak W Mak.

Abstract

The transcription factor nuclear factor-kappaB (NF-kappaB) is essential for immune and inflammatory responses. NF-kappaB essential modulator (NEMO) is a scaffolding component of the IkappaB kinase complex required for NF-kappaB activation in vitro. Because NF-kappaB activation is involved in B cell development and function, we set out to determine whether NEMO is required for these processes. NEMO(-/-) mice die very early during embryogenesis, and fetal livers from NEMO(-/-) embryos can not reconstitute either B or T lymphopoiesis in irradiated host mice. We therefore used NEMO(-/-) embryonic stem cells and the OP9 in vitro differentiation system to demonstrate that NEMO is not required for B cell development but plays an important role in B cell survival.

Entities: Gene Species

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Year: 2003 PMID： 12538858 PMCID： PMC298751 DOI： 10.1073/pnas.0337707100

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

38 in total

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