Literature DB >> 1253814

Photoaffinity labeling of the beta-adrenergic receptors and receptor reserve for isoprenaline.

I Takayanagi, M Yoshioka, K Takagu, Z Tamura.   

Abstract

The beta-adrenergic receptors in the taenia isolated from the guinea pig caecum were irreversibly inactivated by photoaffinity labeling with 1-isoprenaline and 2-(2-hydroxy-3-isopropylaminopropoxy)iodobenzene. The photoinactivation was eliminated in the presence of protectors of the receptors. Photoinactivation caused a considerable parallel shift in the concentration-action curve of 1-isoprenaline. The results possibly point to a certain receptor reserve for 1-isoprenaline.

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Year:  1976        PMID： 1253814     DOI： 10.1016/0014-2999(76)90306-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  4 in total

1.  Photoaffinity label for the beta-adrenergic receptor: synthesis and effects on isoproterenol-stimulated adenylate cyclase.

Authors:  S M Wrenn; C J Homcy
Journal:  Proc Natl Acad Sci U S A       Date:  1980-08       Impact factor: 11.205

2.  Dopamine receptors in canine caudate nucleus.

Authors:  H Maeno
Journal:  Mol Cell Biochem       Date:  1982-03-19       Impact factor: 3.396

3.  Structure-activity studies of new imidazolines on adrenoceptors of rat aorta and human platelets.

Authors:  B V Venkataraman; G Shams; A Hamada; Y Amemiya; V Tantishaiyakul; F Hsu; J Fashempour; K J Romstedt; D D Miller; D R Feller
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-10       Impact factor: 3.000

4.  Quantitative relationship between beta-adrenergic receptor number and physiologic responses as studied with a long-lasting beta-adrenergic antagonist.

Authors:  W L Terasaki; J Linden; G Brooker
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205
  4 in total

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