Literature DB >> 12538022

Non-antibiotic antibacterial activity of dodecyl gallate.

Isao Kubo1, Ken ichi Fujita, Ken ichi Nihei, Noriyoshi Masuoka.   

Abstract

Dodecyl (C(12)) gallate (3,4,5-trihydroxybenzoate) (1) was found to possess antibacterial activity specifically against Gram-positive bacteria, in addition to its potent antioxidant activity. The time-kill curve study indicates that this amphipathic gallate exhibits bactericidal activity against methicillin resistant Staphylococcus aureus (MRSA) strains. Dodecyl (lauryl) gallate inhibited oxygen consumption in whole cells and oxidation of NADH in membrane preparation. The antibacterial activity of this gallate comes in part from its ability to inhibit the membrane respiratory chain. As far as alkyl gallates are concerned, their antimicrobial spectra and potency depend in part on the hydrophobic portion of the molecule.

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Year:  2003        PMID： 12538022     DOI： 10.1016/s0968-0896(02)00436-4

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  9 in total

1.  Bioactive principles in the bark of Pilidiostigma tropicum.

Authors:  William N Setzer; Glenn F Rozmus; Mary C Setzer; Jennifer M Schmidt; Bernhard Vogler; Sabine Reeb; Betsy R Jackes; Anthony K Irvine
Journal:  J Mol Model       Date:  2006-04-07       Impact factor: 1.810

2.  Intake of Natural, Unprocessed Tiger Nuts (Cyperus esculentus L.) Drink Significantly Favors Intestinal Beneficial Bacteria in a Short Period of Time.

Authors:  Marta Selma-Royo; Izaskun García-Mantrana; M Carmen Collado; Gaspar Perez-Martínez
Journal:  Nutrients       Date:  2022-04-20       Impact factor: 6.706

3.  Activity of gallic acid and its ester derivatives in Caenorhabditis elegans and zebrafish (Danio rerio) models.

Authors:  Junya de Lacorte Singulani; Liliana Scorzoni; Paulo César Gomes; Ana Carolina Nazaré; Carlos Roberto Polaquini; Luis Octávio Regasini; Ana Marisa Fusco-Almeida; Maria José Soares Mendes-Giannini
Journal:  Future Med Chem       Date:  2017-10-27       Impact factor: 3.808

4.  Antibacterial activity of alkyl gallates is a combination of direct targeting of FtsZ and permeabilization of bacterial membranes.

Authors:  Ewa Król; Anabela de Sousa Borges; Isabel da Silva; Carlos R Polaquini; Luis O Regasini; Henrique Ferreira; Dirk-Jan Scheffers
Journal:  Front Microbiol       Date:  2015-04-29       Impact factor: 5.640

5.  Lauryl Gallate Activity and Streptococcus mutans: Its Effects on Biofilm Formation, Acidogenicity and Gene Expression.

Authors:  Vika Gabe; Mouhammad Zeidan; Tomas Kacergius; Maksim Bratchikov; Mizied Falah; Anwar Rayan
Journal:  Molecules       Date:  2020-08-13       Impact factor: 4.411

6.  The Impact of Efflux Pump Inhibitors on the Activity of Selected Non-Antibiotic Medicinal Products against Gram-Negative Bacteria.

Authors:  Agnieszka E Laudy; Ewa Kulińska; Stefan Tyski
Journal:  Molecules       Date:  2017-01-11       Impact factor: 4.411

Review 7.  Pharmacological effects of gallic acid in health and diseases: A mechanistic review.

Authors:  Niloofar Kahkeshani; Fatemeh Farzaei; Maryam Fotouhi; Seyedeh Shaghayegh Alavi; Roodabeh Bahramsoltani; Rozita Naseri; Saeideh Momtaz; Zahra Abbasabadi; Roja Rahimi; Mohammad Hosein Farzaei; Anupam Bishayee
Journal:  Iran J Basic Med Sci       Date:  2019-03       Impact factor: 2.699

8.  Purification and characterization of FtsZ from the citrus canker pathogen Xanthomonas citri subsp. citri.

Authors:  Malgorzata M Kopacz; André S G Lorenzoni; Carlos R Polaquini; Luis O Regasini; Dirk-Jan Scheffers
Journal:  Microbiologyopen       Date:  2018-08-07       Impact factor: 3.139

Review 9.  Non-antibiotics, Efflux Pumps and Drug Resistance of Gram-negative Rods.

Authors:  Agnieszka Ewa Laudy
Journal:  Pol J Microbiol       Date:  2018-06-30
  9 in total

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