Literature DB >> 12538012

Inhibitory effects of lapachol derivatives on epstein-barr virus activation.

Elisa Pérez Sacau1, Ana Estévez-Braun, Angel G Ravelo, Esteban A Ferro, Harunkuni Tokuda, Teruo Mukainaka, Hoyoku Nishino.   

Abstract

Sixteen derivatives (2-17) synthesized from the naphthoquinone lapachol (1), were tested for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), as a test for potential cancer chemopreventive agents. They exhibited a variety of inhibitory activities from very high to moderate, which allow us to suggest structure-activity relationships. Ten of these derivatives are reported for the first time, their structures being thoroughly determined by spectroscopic methods.

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Year:  2003        PMID： 12538012     DOI： 10.1016/s0968-0896(02)00542-4

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  9 in total

1.  Parameters determining the relative efficacy of hydroxy-naphthoquinone inhibitors of the cytochrome bc1 complex.

Authors:  Jacques J Kessl; Nikolai V Moskalev; Gordon W Gribble; Mohamed Nasr; Steven R Meshnick; Bernard L Trumpower
Journal:  Biochim Biophys Acta       Date:  2007-02-27

2.  Novel Ionophores Active against La Crosse Virus Identified through Rapid Antiviral Screening.

Authors:  Zachary J Sandler; Mason R Firpo; Oreoluwa S Omoba; Michelle N Vu; Vineet D Menachery; Bryan C Mounce
Journal:  Antimicrob Agents Chemother       Date:  2020-05-21       Impact factor: 5.191

3.  High-throughput screen of natural product libraries for hsp90 inhibitors.

Authors:  Jason Davenport; Maurie Balch; Lakshmi Galam; Antwan Girgis; Jessica Hall; Brian S J Blagg; Robert L Matts
Journal:  Biology (Basel)       Date:  2014-02-10

4.  Chemical composition and antioxidant potentials of Kigelia pinnata root oil and extracts.

Authors:  Olubunmi Atolani; Stephen O Adeyemi; Essiet Akpan; Charles B Adeosun; Gabriel A Olatunji
Journal:  EXCLI J       Date:  2011-11-30       Impact factor: 4.068

5.  Synthesis and pharmacological activity of diterpenylnaphthoquinone derivatives.

Authors:  Mariano Walter Pertino; Cristina Theoduloz; Jose Antonio Palenzuela; Maria del Mar Afonso; Erdem Yesilada; Francisco Monsalve; Paulo González; Daniel Droguett; Guillermo Schmeda-Hirschmann
Journal:  Molecules       Date:  2011-10-13       Impact factor: 4.411

6.  Induced production of antifungal naphthoquinones in the pitchers of the carnivorous plant Nepenthes khasiana.

Authors:  Haviva Eilenberg; Smadar Pnini-Cohen; Yocheved Rahamim; Edward Sionov; Esther Segal; Shmuel Carmeli; Aviah Zilberstein
Journal:  J Exp Bot       Date:  2009-12-16       Impact factor: 6.992

7.  Synthesis and microbiological evaluation of new 2- and 2,3-diphenoxysubstituted naphthalene-1,4-diones with 5-oxopyrrolidine moieties.

Authors:  Aušra Voskienė; Birutė Sapijanskaitė; Vytautas Mickevičius; Ilona Jonuškienė; Maryna Stasevych; Olena Komarovska-Porokhnyavets; Rostyslav Musyanovych; Volodymyr Novikov
Journal:  Molecules       Date:  2012-12-05       Impact factor: 4.411

8.  Evaluation of the anti-inflammatory effects of synthesised tanshinone I and isotanshinone I analogues in zebrafish.

Authors:  Matthew J Foulkes; Faith H Tolliday; Katherine M Henry; Stephen A Renshaw; Simon Jones
Journal:  PLoS One       Date:  2020-10-06       Impact factor: 3.240

9.  COMPARE Analysis, a Bioinformatic Approach to Accelerate Drug Repurposing against Covid-19 and Other Emerging Epidemics.

Authors:  Imad Naasani
Journal:  SLAS Discov       Date:  2020-12-02       Impact factor: 3.341
  9 in total

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