Literature DB >> 12537646

How light reaches the eye and its components.

David H Sliney1.   

Abstract

The human eye is exquisitely sensitive to light (i.e., visible radiant energy), and when dark-adapted, the retina can detect a few photons of blue-green light. It is therefore not at all surprising that ocular tissues are also more vulnerable to ultraviolet (UV) and light damage than the skin. For this reason, humans have evolved with certain anatomical, physiological, and behavioral traits that protect this critical organ from the UV damage that would otherwise be certain from the intense bath of overhead solar ultraviolet radiation (UVR) when we are outdoors during daylight. For example, the UV exposure threshold dose for photokeratitis ("welders' flash" or "snow blindness")--if measured as falling on a horizontal ground surface--would be reached in less than 10 minutes around midday in the summer sun. There are three critical ocular structures that could be affected by UV exposure: the cornea, the lens, and the retina. The cornea transmits radiant energy only at 295 nm and above. The crystalline lens absorbs almost all incident energy to wavelengths of nearly 400 nm. In youth, a very small amount of UV-A reaches the retina, but the lens becomes more absorbing with age. Thus there are intraocular filters that effectively filter different parts of the UV spectrum and allow only of the order of 1% or less to actually reach the retina. Nevertheless, this small fraction of energy--if phototoxic--could still be of concern. Finally, oblique rays entering the eye from the temporal side, can actually reach the equatorial (germinative) area of the lens.

Entities:  

Mesh:

Year:  2002        PMID: 12537646     DOI: 10.1080/10915810290169927

Source DB:  PubMed          Journal:  Int J Toxicol        ISSN: 1091-5818            Impact factor:   2.032


  46 in total

1.  Ultraviolet-sensitive vision in long-lived birds.

Authors:  Livia S Carvalho; Ben Knott; Mathew L Berg; Andrew T D Bennett; David M Hunt
Journal:  Proc Biol Sci       Date:  2010-07-28       Impact factor: 5.349

Review 2.  Retinal light toxicity.

Authors:  P N Youssef; N Sheibani; D M Albert
Journal:  Eye (Lond)       Date:  2010-10-29       Impact factor: 3.775

3.  Light effects on mitochondrial photosensitizers in relation to retinal degeneration.

Authors:  N N Osborne; T A Kamalden; A S A Majid; S del Olmo-Aguado; A G Manso; D Ji
Journal:  Neurochem Res       Date:  2010-10-07       Impact factor: 3.996

Review 4.  A hypothesis to suggest that light is a risk factor in glaucoma and the mitochondrial optic neuropathies.

Authors:  N N Osborne; G Lascaratos; A J Bron; G Chidlow; J P M Wood
Journal:  Br J Ophthalmol       Date:  2006-02       Impact factor: 4.638

5.  Effects of ascorbic acid on UV light-mediated photoreceptor damage in isolated rat retina.

Authors:  Kazuhiro Tokuda; Charles F Zorumski; Yukitoshi Izumi
Journal:  Exp Eye Res       Date:  2007-01-12       Impact factor: 3.467

6.  Phototoxicity in human retinal pigment epithelial cells promoted by hypericin, a component of St. John's wort.

Authors:  Albert R Wielgus; Colin F Chignell; David S Miller; Ben Van Houten; Joel Meyer; Dan-Ning Hu; Joan E Roberts
Journal:  Photochem Photobiol       Date:  2007 May-Jun       Impact factor: 3.421

7.  Characterization of visual pigments, oil droplets, lens and cornea in the whooping crane Grus americana.

Authors:  Megan L Porter; Alexandra C N Kingston; Robert McCready; Evan G Cameron; Christopher M Hofmann; Lauren Suarez; Glenn H Olsen; Thomas W Cronin; Phyllis R Robinson
Journal:  J Exp Biol       Date:  2014-09-29       Impact factor: 3.312

8.  A quantitative assessment of the burden and distribution of Lisch nodules in adults with neurofibromatosis type 1.

Authors:  Sean Boley; Jennifer L Sloan; Alexander Pemov; Douglas R Stewart
Journal:  Invest Ophthalmol Vis Sci       Date:  2009-06-10       Impact factor: 4.799

9.  Evaluation of ultraviolet light toxicity on cultured retinal pigment epithelial and retinal ganglion cells.

Authors:  Sankarathi Balaiya; Ravi K Murthy; Vikram S Brar; Kakarla V Chalam
Journal:  Clin Ophthalmol       Date:  2010-02-02

10.  Difference in phototoxicity of cyclodextrin complexed fullerene [(gamma-CyD)2/C60] and its aggregated derivatives toward human lens epithelial cells.

Authors:  Baozhong Zhao; Yu-Ying He; Colin F Chignell; Jun-Jie Yin; Usha Andley; Joan E Roberts
Journal:  Chem Res Toxicol       Date:  2009-04       Impact factor: 3.739

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