Z F Long1, G Y Qu, M Xu. 1. Department of Gerontology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Abstract
OBJECTIVE: To study the relationship between the level of plasma D-dimer and microangiopathy of the type 2 diabetes mellitus. METHODS: The level of plasma D-dimer and blood viscosity were measured in 52 cases with type 2 diabetes mellitus, and these patients were divided into three groups according to the level of urinary albumin excretion (UAE) together with 15 age-matched healthy volunteers as the control (NC group). RESULTS: In the cases with higher urinary albumin excretion rate, including 28 cases with trace albuminuria (EDN group) and 10 cases with clinical albuminuria (CDN group), plasma D-dimer and blood viscosity were increases than 14 cases without albuminuria (SDM group) and NC group. D-dimer was positively correlated with diabetic retinopathy, Serum insulin and diabetic durations, but not correlated with blood viscosity and fibrinogen. CONCLUSION: The type 2 diabetes mellitus complicated with microangiopathy had a higher level of plasma D-dimer. As a marker of thrombus formation, D-dimer may play an important role in the pathogenesis of diabetic microangiopathy.
OBJECTIVE: To study the relationship between the level of plasma D-dimer and microangiopathy of the type 2 diabetes mellitus. METHODS: The level of plasma D-dimer and blood viscosity were measured in 52 cases with type 2 diabetes mellitus, and these patients were divided into three groups according to the level of urinary albumin excretion (UAE) together with 15 age-matched healthy volunteers as the control (NC group). RESULTS: In the cases with higher urinary albumin excretion rate, including 28 cases with trace albuminuria (EDN group) and 10 cases with clinical albuminuria (CDN group), plasma D-dimer and blood viscosity were increases than 14 cases without albuminuria (SDM group) and NC group. D-dimer was positively correlated with diabetic retinopathy, Serum insulin and diabetic durations, but not correlated with blood viscosity and fibrinogen. CONCLUSION: The type 2 diabetes mellitus complicated with microangiopathy had a higher level of plasma D-dimer. As a marker of thrombus formation, D-dimer may play an important role in the pathogenesis of diabetic microangiopathy.
Authors: Caroline Pereira Domingueti; Luci Maria S Dusse; Rodrigo Bastos Fóscolo; Janice Sepúlveda Reis; Joyce Maria Annichino-Bizzacchi; Fernanda Loureiro de Andrade Orsi; Bruna de Moraes Mazetto; Maria das Graças Carvalho; Karina Braga Gomes; Ana Paula Fernandes Journal: PLoS One Date: 2015-07-13 Impact factor: 3.240