Literature DB >> 12536038

Serotonin receptor mRNA expression in rat dorsal root ganglion neurons.

R Nicholson1, J Small, A K Dixon, D Spanswick, K Lee.   

Abstract

In the present study, we have used in situ hybridization to examine the distribution of serotonin (5-HT) receptors in rat dorsal root ganglion (DRG) neurons. Within DRG neurons, mRNAs for 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT3B and 5-HT4 receptors were readily detected in small (<25 microm), medium (25-45 microm) and large (>45 microm) diameter neurons. In contrast mRNAs for 5-HT1A, 5-HT1E, 5-HT2C, 5-HT5A, 5-HT5B, 5-HT6 and 5-HT7 receptors were undetectable in these neurons. The present study provides an insight into the molecular profile of 5-HT receptor subtypes in neurons responsible for modulating sensory information.

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Year:  2003        PMID： 12536038     DOI： 10.1016/s0304-3940(02)01256-9

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  25 in total

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2.  Serotonergic paraneurones in the female mouse urethral epithelium and their potential role in peripheral sensory information processing.

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3.  TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms.

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4.  Responsiveness of C neurons in rat dorsal root ganglion to 5-hydroxytryptamine-induced pruritic stimuli in vivo.

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5.  Ontogenetic distribution of 5-HT2C, 5-HT5A, and 5-HT7 receptors in the rat hippocampus.

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6.  The complex actions of sumatriptan on rat dural afferents.

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7.  Modulating the Serotonin Receptor Spectrum of Pulicatin Natural Products.

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Review 9.  Serotonin pharmacology in the gastrointestinal tract: a review.

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Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2008-04-09       Impact factor: 3.000

10.  Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior.

Authors:  Thomas Foulkes; Mohammed A Nassar; Tim Lane; Elizabeth A Matthews; Mark D Baker; Volker Gerke; Kenji Okuse; Anthony H Dickenson; John N Wood
Journal:  J Neurosci       Date:  2006-10-11       Impact factor: 6.167
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