Literature DB >> 12535512

A new connection: chaperones meet a mitochondrial receptor.

Wolfgang Voos1.   

Abstract

Cytosolic chaperones stabilize cellular proteins under stress conditions and protect nascent protein chains during normal growth. Recent data from Young et al. (2003) extend the function of chaperones by demonstrating that Hsp90 and Hsp70 specifically interact with the mitochondrial protein import receptor Tom70 at the outer membrane and are required for translocation of precursor proteins.

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Year:  2003        PMID： 12535512     DOI： 10.1016/s1097-2765(03)00002-9

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  14 in total

1.  Mitochondria use different mechanisms for transport of multispanning membrane proteins through the intermembrane space.

Authors:  Ann E Frazier; Agnieszka Chacinska; Kaye N Truscott; Bernard Guiard; Nikolaus Pfanner; Peter Rehling
Journal:  Mol Cell Biol       Date:  2003-11       Impact factor: 4.272

Review 2.  Delivery of drugs and macromolecules to mitochondria.

Authors:  Abhijit Mukhopadhyay; Henry Weiner
Journal:  Adv Drug Deliv Rev       Date:  2007-06-28       Impact factor: 15.470

3.  An unusual TOM20/TOM22 bypass mechanism for the mitochondrial targeting of cytochrome P450 proteins containing N-terminal chimeric signals.

Authors:  Hindupur K Anandatheerthavarada; Naresh Babu V Sepuri; Gopa Biswas; Narayan G Avadhani
Journal:  J Biol Chem       Date:  2008-05-14       Impact factor: 5.157

Review 4.  Bimodal targeting of microsomal cytochrome P450s to mitochondria: implications in drug metabolism and toxicity.

Authors:  Michelle C Sangar; Seema Bansal; Narayan G Avadhani
Journal:  Expert Opin Drug Metab Toxicol       Date:  2010-10       Impact factor: 4.481

Review 5.  Bimodal targeting of cytochrome P450s to endoplasmic reticulum and mitochondria: the concept of chimeric signals.

Authors:  Narayan G Avadhani; Michelle C Sangar; Seema Bansal; Prachi Bajpai
Journal:  FEBS J       Date:  2011-10-24       Impact factor: 5.542

Review 6.  Targeting Hsp70: A possible therapy for cancer.

Authors:  Sanjay Kumar; James Stokes; Udai P Singh; Karyn Scissum Gunn; Arbind Acharya; Upender Manne; Manoj Mishra
Journal:  Cancer Lett       Date:  2016-02-17       Impact factor: 8.679

7.  CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice.

Authors:  Ivor J Benjamin; Yiru Guo; Sathyanarayanan Srinivasan; Sihem Boudina; Ryan P Taylor; Namakkal S Rajasekaran; Roberta Gottlieb; Eric F Wawrousek; E Dale Abel; Roberto Bolli
Journal:  Am J Physiol Heart Circ Physiol       Date:  2007-09-14       Impact factor: 4.733

8.  Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism.

Authors:  Hindupur K Anandatheerthavarada; Naresh Babu V Sepuri; Narayan G Avadhani
Journal:  J Biol Chem       Date:  2009-04-28       Impact factor: 5.157

Review 9.  Functional targeting of the MUC1 oncogene in human cancers.

Authors:  Donald W Kufe
Journal:  Cancer Biol Ther       Date:  2009-07-27       Impact factor: 4.742

10.  Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase.

Authors:  Andrew W Truman; Kolbrun Kristjansdottir; Donald Wolfgeher; Natalia Ricco; Anoop Mayampurath; Samuel L Volchenboum; Josep Clotet; Stephen J Kron
Journal:  J Proteomics       Date:  2014-10-18       Impact factor: 4.044
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