Literature DB >> 12533753

NO-inhibiting and vasotropic activity of some compounds with thioamidine group.

S Ya Proskuryakov1, N G Kucherenko, A I Trishkina, M V Filimonova, A G Shevchuk, L V Shtein, Yu G Verkhovskii, A G Konoplyannikov, A A Mandrugin, V M Fedoseev, V G Skvortsov.   

Abstract

Using the method of electron paramagnetic spectroscopy we demonstrated that thiazine-thiazoline compounds and aminoethyl isothiourea containing the thioamidine group inhibit NO production in the liver of endotoxin-treated mice. Injection of these agents to anesthetized rats increased arterial pressure and enhanced respiration rate. This effect probably reflects inhibition of not only inducible, but also the constitutive synthesis of NO by compounds with thioamidine group.

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Year:  2002        PMID： 12533753     DOI： 10.1023/a:1021943811672

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  2 in total

1.  1-Isobutanoil-2-isopropylisothiourea Phosphate, T1082: A Safe and Effective Prevention of Radiotherapy Complications in Oncology.

Authors:  Marina Filimonova; Alina Saburova; Ljudmila Shevchenko; Victoria Makarchuk; Anna Shitova; Olga Soldatova; Vitaly Rybachuk; Alexander Kosachenko; Kirill Nikolaev; Grigory Demyashkin; Vyacheslav Saburov; Sergey Koryakin; Petr Shegay; Andrey Kaprin; Sergey Ivanov; Alexander Filimonov
Journal:  Int J Mol Sci       Date:  2022-02-28       Impact factor: 5.923

2.  Preclinical studies of NOS inhibitor T1059 vasopressor activity on the models of acute hemorrhagic shock in rats and dogs.

Authors:  Marina Filimonova; Ljudmila Shevchenko; Victoria Makarchuk; Alina Saburova; Petr Shegay; Andrey Kaprin; Sergey Ivanov; Alexander Filimonov
Journal:  Front Pharmacol       Date:  2022-09-30       Impact factor: 5.988
  2 in total

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