AIM: To investigate the expression of 1A6 gene in the lesions during the development of intestinal gastric carcinoma. METHODS: One hundred and thirty-six cases of intestinal metaplasia (IM) from surgical resections and biopsy were classified by mucous staining. Expression of 1A6 in all cases was detected using immunohistochemical S-P method. RESULTS: The positive rates of 1A6 in normal and superficial gastritis (SG), severe atrophic gastritis (SAG), type I, II, III IM, dysplasia (Dys) and intestinal gastric carcinoma (IGC) were 12.2 %, 16.7 %, 7.1 %, 22.6 %, 47.8 %, 46.9 % and 60.8 %, respectively. A significant difference among type III IM and SG, SAG, type I and II IM was found (P<0.01), the difference between type III and Dys, IGC being not significant. CONCLUSION: As a new tumor-related gene, expression of 1A6 may be an effective parameter to predict the malignant transformation of precancerous lesion to gastric carcinoma.
AIM: To investigate the expression of 1A6 gene in the lesions during the development of intestinal gastric carcinoma. METHODS: One hundred and thirty-six cases of intestinal metaplasia (IM) from surgical resections and biopsy were classified by mucous staining. Expression of 1A6 in all cases was detected using immunohistochemical S-P method. RESULTS: The positive rates of 1A6 in normal and superficial gastritis (SG), severe atrophic gastritis (SAG), type I, II, III IM, dysplasia (Dys) and intestinal gastric carcinoma (IGC) were 12.2 %, 16.7 %, 7.1 %, 22.6 %, 47.8 %, 46.9 % and 60.8 %, respectively. A significant difference among type III IM and SG, SAG, type I and II IM was found (P<0.01), the difference between type III and Dys, IGC being not significant. CONCLUSION: As a new tumor-related gene, expression of 1A6 may be an effective parameter to predict the malignant transformation of precancerous lesion to gastric carcinoma.
Authors: M Rugge; P Correa; M F Dixon; T Hattori; G Leandro; K Lewin; R H Riddell; P Sipponen; H Watanabe Journal: Am J Surg Pathol Date: 2000-02 Impact factor: 6.394