BACKGROUND: Many reports support the clinical validity of volumetric MRI measurements in Alzheimer's disease. OBJECTIVE: To integrate functional brain imaging data derived from magnetoencephalography (MEG) and volumetric data in patients with Alzheimer's disease and in age matched controls. METHODS: MEG data were obtained in the context of a probe-letter memory task. Volumetric measurements were obtained for lateral and mesial temporal lobe regions. RESULTS: As expected, Alzheimer's disease patients showed greater hippocampal atrophy than controls bilaterally. MEG derived indices of the degree of activation in left parietal and temporal lobe areas, occurring after 400 ms from stimulus onset, correlated significantly with the relative volume of lateral and mesial temporal regions. In addition, the size of the right hippocampus accounted for a significant portion of the variance in cognitive scores independently of brain activity measures. CONCLUSIONS: These data support the view that there is a relation between hippocampal atrophy and the degree of neurophysiological activity in the left temporal lobe.
BACKGROUND: Many reports support the clinical validity of volumetric MRI measurements in Alzheimer's disease. OBJECTIVE: To integrate functional brain imaging data derived from magnetoencephalography (MEG) and volumetric data in patients with Alzheimer's disease and in age matched controls. METHODS: MEG data were obtained in the context of a probe-letter memory task. Volumetric measurements were obtained for lateral and mesial temporal lobe regions. RESULTS: As expected, Alzheimer's diseasepatients showed greater hippocampal atrophy than controls bilaterally. MEG derived indices of the degree of activation in left parietal and temporal lobe areas, occurring after 400 ms from stimulus onset, correlated significantly with the relative volume of lateral and mesial temporal regions. In addition, the size of the right hippocampus accounted for a significant portion of the variance in cognitive scores independently of brain activity measures. CONCLUSIONS: These data support the view that there is a relation between hippocampal atrophy and the degree of neurophysiological activity in the left temporal lobe.
Authors: F Maestú; A Fernández; P G Simos; P Gil-Gregorio; C Amo; R Rodriguez; J Arrazola; T Ortiz Journal: Neuroreport Date: 2001-12-21 Impact factor: 1.837
Authors: P M Thompson; M S Mega; R P Woods; C I Zoumalan; C J Lindshield; R E Blanton; J Moussai; C J Holmes; J L Cummings; A W Toga Journal: Cereb Cortex Date: 2001-01 Impact factor: 5.357
Authors: G Rodriguez; P Vitali; P Calvini; C Bordoni; N Girtler; G Taddei; G Mariani; F Nobili Journal: Psychiatry Res Date: 2000-12-04 Impact factor: 3.222
Authors: R J Killiany; T Gomez-Isla; M Moss; R Kikinis; T Sandor; F Jolesz; R Tanzi; K Jones; B T Hyman; M S Albert Journal: Ann Neurol Date: 2000-04 Impact factor: 10.422
Authors: Thomas W Mitchell; Elliott J Mufson; Julie A Schneider; Elizabeth J Cochran; Jonathan Nissanov; Li-Ying Han; Julia L Bienias; Virginia M -Y Lee; John Q Trojanowski; David A Bennett; Steven E Arnold Journal: Ann Neurol Date: 2002-02 Impact factor: 10.422
Authors: Edward Zamrini; Fernando Maestu; Eero Pekkonen; Michael Funke; Jyrki Makela; Myles Riley; Ricardo Bajo; Gustavo Sudre; Alberto Fernandez; Nazareth Castellanos; Francisco Del Pozo; C J Stam; Bob W van Dijk; Anto Bagic; James T Becker Journal: Int J Alzheimers Dis Date: 2011-04-10