Peter D Wall1, Eva K Pressman, James R Woods. 1. Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Rochester Medical Center, Rochester, New York, USA. Peter_Wall@urmc.rochester.edu
Abstract
AIM: To discuss the role of oxidant stress in preterm, premature rupture of the membranes (PPROM). RESULTS: There is evidence to suggest that preterm, premature rupture of the membranes occurs secondary to focal collagen damage in the fetal membranes. CONCLUSION: Oxidant stress caused by increased ROS formation and/or antioxidant depletion may disrupt collagen and cause premature membrane rupture. We propose that supplementation with vitamins C and E may synergistically protect the fetal membranes, and decrease the risks of PPROM.
AIM: To discuss the role of oxidant stress in preterm, premature rupture of the membranes (PPROM). RESULTS: There is evidence to suggest that preterm, premature rupture of the membranes occurs secondary to focal collagen damage in the fetal membranes. CONCLUSION: Oxidant stress caused by increased ROS formation and/or antioxidant depletion may disrupt collagen and cause premature membrane rupture. We propose that supplementation with vitamins C and E may synergistically protect the fetal membranes, and decrease the risks of PPROM.
Authors: Joseph A Spinnato; Salvio Freire; Joao Luiz Pinto e Silva; Marilza Vieira Cunha Rudge; Sérgio Martins-Costa; Matthew A Koch; Norman Goco; Cleide de Barros Santos; Jose Guilherme Cecatti; Roberto Costa; José Geraldo Ramos; Nancy Moss; Baha M Sibai Journal: Am J Obstet Gynecol Date: 2008-10 Impact factor: 8.661
Authors: Ramkumar Menon; Istvan Boldogh; Rheanna Urrabaz-Garza; Jossimara Polettini; Tariq Ali Syed; George R Saade; John Papaconstantinou; Robert N Taylor Journal: PLoS One Date: 2013-12-27 Impact factor: 3.240