BACKGROUND: IL-1-cytokines are strongly involved in carcinogenesis and tumor genesis. In this systematic review we will describe the role of IL-1 RA within the cytokine network and its predictive and prognostic value in cancer. MATERIALS AND METHODS: We analysed preclinical and clinical studies. RESULTS: A polymorphism is present in intron 2 of the human IL-1RA gene. The IL-1RA allele 2 has an influence on the IL-1RA plasma level. The IL-1 beta level is elevated at the homozygous for IL-1RA, allele 2 (IL-1RN*2). The IL-1 gene cluster polymorphism is associated with gastric cancer. Carriers of IL-1 1B- 511T and IL-1RN*2 homozygotes have an increased risk of developing gastric cancer. Patients with a heterozygosity of allele 2 for IL-1 RA (IL-RA1/2) have an increased risk of cervical cancer. There are negative associations between IL-1 RA polymorphism and the occurrence of ovarian cancer. CONCLUSION: The polymorphism of IL-1RA seems to be involved in the induction of different solid tumors.
BACKGROUND: IL-1-cytokines are strongly involved in carcinogenesis and tumor genesis. In this systematic review we will describe the role of IL-1 RA within the cytokine network and its predictive and prognostic value in cancer. MATERIALS AND METHODS: We analysed preclinical and clinical studies. RESULTS: A polymorphism is present in intron 2 of the humanIL-1RA gene. The IL-1RA allele 2 has an influence on the IL-1RA plasma level. The IL-1 beta level is elevated at the homozygous for IL-1RA, allele 2 (IL-1RN*2). The IL-1 gene cluster polymorphism is associated with gastric cancer. Carriers of IL-1 1B- 511T and IL-1RN*2 homozygotes have an increased risk of developing gastric cancer. Patients with a heterozygosity of allele 2 for IL-1 RA (IL-RA1/2) have an increased risk of cervical cancer. There are negative associations between IL-1 RA polymorphism and the occurrence of ovarian cancer. CONCLUSION: The polymorphism of IL-1RA seems to be involved in the induction of different solid tumors.
Authors: Hugo Sousa; Alexandra M Santos; Raquel Catarino; Daniela Pinto; José Moutinho; Paulo Canedo; José Carlos Machado; Rui Medeiros Journal: Mol Biol Rep Date: 2012-10-10 Impact factor: 2.316
Authors: Alice Nomura; Vineet K Gupta; Patricia Dauer; Nikita S Sharma; Vikas Dudeja; Nipun Merchant; Ashok K Saluja; Sulagna Banerjee Journal: Mol Cancer Res Date: 2017-09-28 Impact factor: 5.852
Authors: M Czajkowski; P Wierzbicki; A Kotulak-Chrząszcz; K Czajkowska; M Bolcewicz; J Kłącz; K Kreft; A Lewandowska; B Nedoszytko; M Sokołowska-Wojdyło; Z Kmieć; L Kalinowski; R J Nowicki; M Matuszewski Journal: Int Urol Nephrol Date: 2022-02-01 Impact factor: 2.370