Literature DB >> 12529139

A concise formal total synthesis of TMC-95A/B proteasome inhibitors.

Brian K Albrecht1, Robert M Williams.   

Abstract

[reaction: see text] A formal total synthesis of proteasome inhibitors TMC-95A/B is described. The synthesis features a stereoselective modified Julia olefination and a diastereoselective dihydroxylation to construct the highly oxidized tryptophan residue.

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Year:  2003        PMID： 12529139     DOI： 10.1021/ol0272545

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  A concise, total synthesis of the TMC-95A/B proteasome inhibitors.

Authors:  Brian K Albrecht; Robert M Williams
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-26       Impact factor: 11.205

2.  Total synthesis of TMC-95A and -B via a new reaction leading to Z-enamides. Some preliminary findings as to SAR.

Authors:  Songnian Lin; Zhi-Qiang Yang; Benjamin H B Kwok; Michael Koldobskiy; Craig M Crews; Samuel J Danishefsky
Journal:  J Am Chem Soc       Date:  2004-05-26       Impact factor: 15.419

3.  Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors.

Authors:  Grace E Hubbell; Jetze J Tepe
Journal:  RSC Chem Biol       Date:  2020-09-16

4.  Cu(ii)-thiophene-2,5-bis(amino-alcohol) mediated asymmetric Aldol reaction and Domino Knoevenagel Michael cyclization: a new highly efficient Lewis acid catalyst.

Authors:  Abdullah Mohammed Al-Majid; Abdullah Saleh Alammari; Saeed Alshahrani; Matti Haukka; Mohammad Shahidul Islam; Assem Barakat
Journal:  RSC Adv       Date:  2022-02-21       Impact factor: 3.361
  4 in total

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