Literature DB >> 12529120

Synthesis of long-chain fatty acid enol esters isolated from an environmental DNA clone.

Sean F Brady1, Jon Clardy.   

Abstract

[structure: see text] Long-chain fatty acid enol ester 1 is the major metabolite of a new family of small molecules isolated from the heterologous expression of environmentally derived DNA. A versatile synthesis of 1, in which an aromatic acetaldehyde is O-acylated with a long-chain acyl chloride allowed for the rapid construction of both the isolated product (1) and a number of structural analogues (including 8, 17, and 18).

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Year:  2003        PMID： 12529120     DOI： 10.1021/ol0267681

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  5 in total

1.  Long-chain N-acyltyrosine synthases from environmental DNA.

Authors:  Sean F Brady; Carol J Chao; Jon Clardy
Journal:  Appl Environ Microbiol       Date:  2004-11       Impact factor: 4.792

2.  Synthetic libraries of tyrosine-derived bacterial metabolites.

Authors:  Savvas N Georgiades; Jon Clardy
Journal:  Bioorg Med Chem Lett       Date:  2007-10-22       Impact factor: 2.823

3.  Characterization of a novel type of oxidative decarboxylase involved in the biosynthesis of the styryl moiety of chondrochloren from an acylated tyrosine.

Authors:  Shwan Rachid; Ole Revermann; Christina Dauth; Uli Kazmaier; Rolf Müller
Journal:  J Biol Chem       Date:  2010-01-15       Impact factor: 5.157

Review 4.  Bioprospecting potential of the soil metagenome: novel enzymes and bioactivities.

Authors:  Myung Hwan Lee; Seon-Woo Lee
Journal:  Genomics Inform       Date:  2013-09-30

Review 5.  Emerging strategies and integrated systems microbiology technologies for biodiscovery of marine bioactive compounds.

Authors:  Javier Rocha-Martin; Catriona Harrington; Alan D W Dobson; Fergal O'Gara
Journal:  Mar Drugs       Date:  2014-06-10       Impact factor: 5.118
  5 in total

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